Jensen P, Clausen O P, Geiran O, Simonsen S, Relbo A, Hansen S, Langeland T
Department of Dermatology, Rikshospitalet, University of Oslo, Norway.
Acta Derm Venereol. 1995 Sep;75(5):400-3. doi: 10.2340/0001555575400403.
All Norweigian heart transplant recipients with more than one year's survival (n = 140) were investigated for dermatological disorders. Observation time after transplantation was 1-10 years (mean 5.0 years). Patients alive at the end of 1993 (n = 122) were examined clinically, and medical records for all patients were reviewed. The histopathological diagnoses of excised skin specimens were reevaluated. Malignant skin tumours (i.e. basal cell carcinoma, squamous cell carcinoma and malignant melanoma) and/or premalignant skin tumours (i.e. morbus Bowen (carcinoma in situ), solar keratosis and keratoacanthoma) were found in 34 patients (24.3%), of which 18 patients (12.9%) had malignant skin tumours. Seventeen lesions diagnosed as keratoacanthoma and two lesions diagnosed as morbus Bowen had primarily been diagnosed as squamous cell carcinoma. Five patients (3.6%) had multiple keratoacanthomas. Other frequent dermatological diagnoses included hypertrichosis (86.9%), steroid-induced skin features (59.8%), common warts (42.6%) and seborrheic skin disorders (20.5%). This study demonstrates the importance of dermatological surveillance in the follow-up of heart transplant recipients.
对所有存活超过一年的挪威心脏移植受者（n = 140）进行了皮肤病学疾病调查。移植后的观察时间为1至10年（平均5.0年）。对1993年底仍存活的患者（n = 122）进行了临床检查，并查阅了所有患者的病历。对切除的皮肤标本的组织病理学诊断进行了重新评估。在34例患者（24.3%）中发现了恶性皮肤肿瘤（即基底细胞癌、鳞状细胞癌和恶性黑色素瘤）和/或癌前皮肤肿瘤（即鲍恩病（原位癌）、日光性角化病和角化棘皮瘤），其中18例患者（12.9%）患有恶性皮肤肿瘤。17个诊断为角化棘皮瘤的病变和2个诊断为鲍恩病的病变最初被诊断为鳞状细胞癌。5例患者（3.6%）患有多发性角化棘皮瘤。其他常见的皮肤病学诊断包括多毛症（86.9%）、类固醇引起的皮肤特征（59.8%）、寻常疣（42.6%）和脂溢性皮肤病（20.5%）。这项研究证明了皮肤病学监测在心脏移植受者随访中的重要性。
