Laboratoire de Synthèse et Réactivité Organiques, Institut de Chimie de Strasbourg, associé au CNRS, 4 rue Blaise Pascal, 67000 Strasbourg, France.
Chemistry. 2011 Feb 7;17(6):1907-14. doi: 10.1002/chem.201002649. Epub 2011 Jan 12.
Scandium(III)-exchanged zeolite was used as heterogeneous ligand-free catalysts for the [4+2]cyclocondensation of amines and aldehydes with alkenes through the in situ formation of imines. Such catalysts offered a versatile, efficient, and highly regio- and stereoselective synthesis of tetrahydroquinoline derivatives. These catalysts exhibited a wide scope and compatibility with functional groups. They are very simple to use, easy to remove (by simple filtration), and they are recyclable (up to three times without loss of activity).
钪（III）交换沸石被用作非均相配体自由催化剂，通过亚胺的原位形成，用于胺和醛与烯烃的[4+2]环缩合反应。这种催化剂提供了一种多功能、高效、高度区域和立体选择性的四氢喹啉衍生物合成方法。这些催化剂具有广泛的适用范围和官能团兼容性。它们非常易于使用（通过简单过滤即可去除），可回收（可达三次而不损失活性）。
