King J S, Mortimer R K
Graduate Group in Biophysics, University of California, Berkeley 94720.
Genetics. 1990 Dec;126(4):1127-38. doi: 10.1093/genetics/126.4.1127.
A model of chiasma interference is proposed and simulated on a computer. The model uses random events and a polymerization reaction to regulate meiotic recombination between and along chromosomes. A computer simulation of the model generates distributions of crossovers per chromosome arm, position of events along the chromosome arm, distance between crossovers in two-event tetrads, and coincidence as a function of distance. Outputs from the simulation are compared to data from Saccharomyces cerevisiae and the X chromosome of Drosophila melanogaster. The simulation demonstrates that the proposed model can produce the regulation of recombination observed in both genetic and cytological experiments. While the model was quantitatively compared to data from only Drosophila and Saccharomyces, the regulation observed in these species is qualitatively similar to the regulation of recombination observed in other organisms.
提出了一种交叉干涉模型并在计算机上进行模拟。该模型利用随机事件和聚合反应来调控染色体间及沿染色体的减数分裂重组。对该模型的计算机模拟生成了每条染色体臂上的交叉分布、事件沿染色体臂的位置、双事件四联体中交叉之间的距离以及作为距离函数的符合系数。将模拟输出与来自酿酒酵母和黑腹果蝇X染色体的数据进行比较。模拟结果表明，所提出的模型能够产生在遗传和细胞学实验中观察到的重组调控。虽然该模型仅与来自果蝇和酿酒酵母的数据进行了定量比较，但在这些物种中观察到的调控在定性上与在其他生物体中观察到的重组调控相似。
