McKim K S, Green-Marroquin B L, Sekelsky J J, Chin G, Steinberg C, Khodosh R, Hawley R S
Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
Science. 1998 Feb 6;279(5352):876-8. doi: 10.1126/science.279.5352.876.
Although in Saccharomyces cerevisiae the initiation of meiotic recombination, as indicated by double-strand break formation, appears to be functionally linked to the initiation of synapsis, meiotic chromosome synapsis in Drosophila females occurs in the absence of meiotic exchange. Electron microscopy of oocytes from females homozygous for either of two meiotic mutants (mei-W68 and mei-P22), which eliminate both meiotic crossing over and gene conversion, revealed normal synaptonemal complex formation. Thus, synapsis in Drosophila is independent of meiotic recombination, consistent with a model in which synapsis is required for the initiation of meiotic recombination. Furthermore, the basic processes of early meiosis may have different functional or temporal relations, or both, in yeast and Drosophila.
尽管在酿酒酵母中，如双链断裂形成所表明的那样，减数分裂重组的起始似乎在功能上与联会的起始相关，但果蝇雌性减数分裂染色体联会在没有减数分裂交换的情况下也会发生。对两个减数分裂突变体（mei-W68和mei-P22）纯合雌性的卵母细胞进行电子显微镜观察，这两个突变体消除了减数分裂交叉和基因转换，结果显示联会复合体形成正常。因此，果蝇中的联会独立于减数分裂重组，这与联会是减数分裂重组起始所必需的模型一致。此外，酵母和果蝇中减数分裂早期的基本过程可能具有不同的功能或时间关系，或者两者都不同。
