Medeiros Patricia V, Abagge Kerstin T, Carvalho Vânia O, Bonfim Carmem M, Raboni Sonia M
Clinics Hospital/University Federal of Parana, Curitiba, Brazil.
Pediatr Dermatol. 2011 Jan-Feb;28(1):76-7. doi: 10.1111/j.1525-1470.2010.01252.x. Epub 2010 Nov 12.
A 14-year-old girl with Fanconi anemia was submitted to allogeneic hematopoietic stem cell transplantation. After 17 days she developed hemorrhagic cystitis due to polyoma BK virus (BKV), confirmed by PCR (polymerase chain reaction). Two weeks after the appearance of the urinary symptoms the patient presented numerous papules and vesicles on both hands and feet. PCR of the skin lesions and plasma was positive for BKV. The relationship of BKV with frequent infections in immunocompromised patients is well established. The positive PCR of vesicular fluid suggests that this was the causative agent of the skin lesion in this case. There are no reports of skin lesions with positive PCR for BKV.
一名患有范可尼贫血的14岁女孩接受了异基因造血干细胞移植。17天后，她因多瘤BK病毒（BKV）感染出现出血性膀胱炎，通过聚合酶链反应（PCR）得以确诊。出现泌尿系统症状两周后，患者双手和双脚出现大量丘疹和水疱。皮肤病变部位及血浆的PCR检测显示BKV呈阳性。BKV与免疫功能低下患者频繁感染之间的关系已得到充分证实。水疱液的PCR检测呈阳性表明，在该病例中，BKV是皮肤病变的病原体。目前尚无BKV PCR检测呈阳性的皮肤病变报告。
