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血液系统恶性肿瘤患者的接合菌病(毛霉菌病)

[Zygomycosis (mucormycosis) in patients with haematologic malignancy].

作者信息

Jensen Eva Magrethe Precht, Clemmensen Stine, Bjørndal Kristine, Krogdahl Annelise

机构信息

Afdeling for Klinisk Patologi, Odense Universitetshospital, Odense C, Denmark.

出版信息

Ugeskr Laeger. 2011 Jan 31;173(5):353-4.

Abstract

Zygomycosis is an invasive and increasingly emerging life-threatening infection. Diabetes is the most common risk factor; however, zygomycosis has increased among patients with haematologic malignancy, which is now the second most common risk factor with an incidence of 16%. Rapid diagnosis and treatment are essential for patient survival. In the Danish literature, only a few cases have been reported. We present two cases of zygomycosis, both with a fatal outcome, and we discuss the pathogenesis and treatment of invasive zygomycosis.

摘要

接合菌病是一种侵袭性且日益常见的危及生命的感染。糖尿病是最常见的危险因素;然而,血液系统恶性肿瘤患者中的接合菌病有所增加,目前这是第二常见的危险因素,发病率为16%。快速诊断和治疗对患者生存至关重要。在丹麦文献中,仅报道过少数病例。我们呈现两例接合菌病病例,均预后不良,并且我们讨论侵袭性接合菌病的发病机制和治疗。

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