Beijing Pediatric Research Institute, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China.
Vaccine. 2011 Mar 9;29(12):2296-301. doi: 10.1016/j.vaccine.2011.01.027. Epub 2011 Jan 26.
A prospective study was performed to determine serotype distribution and antimicrobial resistance in Streptococcus pneumoniae (S. pneumoniae) from Chinese children <5 years old meeting pneumonia criteria. A total of 3865 children were enrolled and 338 S. pneumoniae isolates were obtained. The most frequent serotypes were 19F (55.6%), 19A (13.9%), 23F (10.1%), 6B (4.7%), and 14 (3.6%). The 7-, 10- and 13-valent conjugate vaccines, respectively, covered 76.3%, 76.9%, and 92.3% of isolates. Out of the isolates, six (1.8%) were penicillin resistant. All except 1 of the isolates were resistant to erythromycin. Serotype 19A showed the highest drug resistance. The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A.
一项前瞻性研究旨在确定符合肺炎标准的中国 5 岁以下儿童肺炎链球菌（S. pneumoniae）的血清型分布和抗生素耐药性。共纳入 3865 例儿童，获得 338 株 S. pneumoniae 分离株。最常见的血清型为 19F（55.6%）、19A（13.9%）、23F（10.1%）、6B（4.7%）和 14（3.6%）。7 价、10 价和 13 价结合疫苗分别覆盖了 76.3%、76.9%和 92.3%的分离株。在分离株中，有 6 株（1.8%）对青霉素耐药。除 1 株外，所有分离株均对红霉素耐药。血清型 19A 显示出最高的药物耐药性。使用 PCV7 有可能预防大量肺炎球菌感染。然而，由于 19A 较高的发生率，PCV13 可能会在中国预防更多的肺炎球菌疾病。
