College of Biological and Environmental Engineering, Research Centre of Environmental Science, Zhejiang University of Technology, Hangzhou, People's Republic of China.
Aquat Toxicol. 2011 Feb;101(3-4):493-9. doi: 10.1016/j.aquatox.2010.12.004. Epub 2010 Dec 24.
According to some previous studies, titanium dioxide (TiO(2)) nanoparticles (NPs) would be of low to medium ecological toxicity in short-term tests. But the long-term risks of TiO(2) NPs that is currently unknown. In this study, we used the zebrafish (Danio rerio) as in vivo model to assess the chronic toxicity of TiO(2) NPs. Our results revealed that there are obvious adverse effect to zebrafish, including concentration-dependent and time-dependent inhibition of growth and decrease the liver weight ratio of zebrafish. Meanwhile, only the gills displayed histopathologic change including thickening of oedema and the gill lamellae. ICP-MS examination showed that TiO(2) NPs were accumulated and distributed in gill, liver, heart as well as brain. Our present study suggested that the TiO(2) NPs could translocate among organs and pass through the blood-brain and the blood-heart barrier after long-term exposure. Given the widespread use of TiO(2) NPs, a systematic, coherent, and tested foundation for managing the uncertain health and environmental aspects of TiO(2) NPs is necessary.
根据一些先前的研究，在短期试验中，二氧化钛（TiO(2)）纳米颗粒（NPs）的生态毒性属于低到中等水平。但目前还不清楚 TiO(2) NPs 的长期风险。在这项研究中，我们使用斑马鱼（Danio rerio）作为体内模型来评估 TiO(2) NPs 的慢性毒性。我们的结果表明，TiO(2) NPs 对斑马鱼有明显的不良影响，包括浓度和时间依赖性的生长抑制和斑马鱼肝重比降低。同时，只有鳃显示出组织病理学变化，包括水肿和鳃片增厚。ICP-MS 检查显示 TiO(2) NPs 被积累和分布在鳃、肝、心和脑。我们的研究表明，TiO(2) NPs 在长期暴露后可以在器官之间转移，并穿过血脑和血心屏障。鉴于 TiO(2) NPs 的广泛应用，有必要为管理 TiO(2) NPs 不确定的健康和环境方面建立一个系统的、连贯的和经过测试的基础。
