臭氧对出生后发育期间哮喘的生化影响。
Biochemical effects of ozone on asthma during postnatal development.
作者信息
Auten Richard L, Foster W Michael
机构信息
Department of Pediatrics (Neonatal Medicine), Duke University, DUMC Box 3373, Durham, NC 27710, USA.
出版信息
Biochim Biophys Acta. 2011 Nov;1810(11):1114-9. doi: 10.1016/j.bbagen.2011.01.008. Epub 2011 Jan 27.
Abstract
BACKGROUND
Ozone exposure during early life has the potential to contribute to the development of asthma as well as to exacerbate underlying allergic asthma.
SCOPE OF REVIEW
Developmentally regulated aspects of sensitivity to ozone exposure and downstream biochemical and cellular responses.
MAJOR CONCLUSIONS
Developmental differences in antioxidant defense responses, respiratory physiology, and vulnerabilities to cellular injury during particular developmental stages all contribute to disparities in the health effects of ozone exposure between children and adults.
GENERAL SIGNIFICANCE
Ozone exposure has the capacity to affect multiple aspects of the "effector arc" of airway hyperresponsiveness, ranging from initial epithelial damage and neural excitation to neural reprogramming during infancy. This article is part of a Special Issue entitled: Biochemistry of Asthma.
摘要
背景
生命早期暴露于臭氧环境中可能会促使哮喘的发生，并加重潜在的过敏性哮喘。
综述范围
对臭氧暴露敏感性的发育调控方面以及下游生化和细胞反应。
主要结论
抗氧化防御反应、呼吸生理学以及特定发育阶段细胞损伤易感性方面的发育差异，均导致儿童和成人臭氧暴露健康影响的差异。
普遍意义
臭氧暴露能够影响气道高反应性“效应弧”的多个方面，从最初的上皮损伤和神经兴奋到婴儿期的神经重编程。本文是名为《哮喘的生物化学》特刊的一部分。
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本文引用的文献
1
Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling.
Dis Model Mech. 2010 Sep-Oct;3(9-10):545-56. doi: 10.1242/dmm.006031. Epub 2010 Aug 10.
2
Functional analysis of two distinct bronchiolar progenitors during lung injury and repair.
Am J Respir Cell Mol Biol. 2011 Jun;44(6):794-803. doi: 10.1165/rcmb.2010-0098OC. Epub 2010 Jul 23.
3
Airway mast cells in a rhesus model of childhood allergic airways disease.
Toxicol Sci. 2010 Jul;116(1):313-22. doi: 10.1093/toxsci/kfq119. Epub 2010 Apr 19.
4
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L17-24. doi: 10.1152/ajplung.00216.2009. Epub 2010 Apr 9.
5
The effect of early-life stress on airway inflammation in adult mice.
Neuroimmunomodulation. 2010;17(4):229-39. doi: 10.1159/000290039. Epub 2010 Mar 5.
6
Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma.
J Allergy Clin Immunol. 2010 Mar;125(3):626-35. doi: 10.1016/j.jaci.2009.10.065. Epub 2010 Feb 11.
7
Sensory neural responses to ozone exposure during early postnatal development in rat airways.
Am J Respir Cell Mol Biol. 2010 Dec;43(6):750-7. doi: 10.1165/rcmb.2009-0191OC. Epub 2010 Jan 29.
8
The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001-2004.
Environ Res. 2010 Apr;110(3):294-301. doi: 10.1016/j.envres.2010.01.001. Epub 2010 Feb 1.
9
Relationship between ambient ozone concentrations and daily hospital admissions for childhood asthma/atopic dermatitis in two cities of Korea during 2004-2005.
Int J Environ Health Res. 2010 Feb;20(1):1-11. doi: 10.1080/09603120903254033.
10
Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels.
J Physiol. 2010 Feb 1;588(Pt 3):423-33. doi: 10.1113/jphysiol.2009.183301. Epub 2009 Dec 14.
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