臭氧对出生后发育期间哮喘的生化影响。
Biochemical effects of ozone on asthma during postnatal development.
作者信息
Auten Richard L, Foster W Michael
机构信息
Department of Pediatrics (Neonatal Medicine), Duke University, DUMC Box 3373, Durham, NC 27710, USA.
出版信息
Biochim Biophys Acta. 2011 Nov;1810(11):1114-9. doi: 10.1016/j.bbagen.2011.01.008. Epub 2011 Jan 27.
Abstract
BACKGROUND
Ozone exposure during early life has the potential to contribute to the development of asthma as well as to exacerbate underlying allergic asthma.
SCOPE OF REVIEW
Developmentally regulated aspects of sensitivity to ozone exposure and downstream biochemical and cellular responses.
MAJOR CONCLUSIONS
Developmental differences in antioxidant defense responses, respiratory physiology, and vulnerabilities to cellular injury during particular developmental stages all contribute to disparities in the health effects of ozone exposure between children and adults.
GENERAL SIGNIFICANCE
Ozone exposure has the capacity to affect multiple aspects of the "effector arc" of airway hyperresponsiveness, ranging from initial epithelial damage and neural excitation to neural reprogramming during infancy. This article is part of a Special Issue entitled: Biochemistry of Asthma.
摘要
背景
生命早期暴露于臭氧环境中可能会促使哮喘的发生，并加重潜在的过敏性哮喘。
综述范围
对臭氧暴露敏感性的发育调控方面以及下游生化和细胞反应。
主要结论
抗氧化防御反应、呼吸生理学以及特定发育阶段细胞损伤易感性方面的发育差异，均导致儿童和成人臭氧暴露健康影响的差异。
普遍意义
臭氧暴露能够影响气道高反应性“效应弧”的多个方面，从最初的上皮损伤和神经兴奋到婴儿期的神经重编程。本文是名为《哮喘的生物化学》特刊的一部分。
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