影响过敏性哮喘免疫发病机制的围产期和幼儿期环境因素。
Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis.
作者信息
Gaffin Jonathan M, Kanchongkittiphon Watcharoot, Phipatanakul Wanda
机构信息
Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA; USA; Harvard Medical School, Boston, MA, USA.
Division of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Int Immunopharmacol. 2014 Sep;22(1):21-30. doi: 10.1016/j.intimp.2014.06.005. Epub 2014 Jun 19.
BACKGROUND
The prevalence of asthma has increased dramatically over the past several decades. While hereditary factors are highly important, the rapid rise outstrips the pace of genomic variation. Great emphasis has been placed on potential modifiable early life exposures leading to childhood asthma.
METHODS
We reviewed the recent medical literature for important studies discussing the role of the perinatal and early childhood exposures and the inception of childhood asthma.
RESULTS AND DISCUSSION
Early life exposure to allergens (house dust mite (HDM), furred pets, cockroach, rodent and mold), air pollution (nitrogen dioxide (NO(2)), ozone (O(3)), volatile organic compounds (VOCs), and particulate matter (PM)) and viral respiratory tract infections (Respiratory syncytial virus (RSV) and human rhinovirus (hRV)) has been implicated in the development of asthma in high risk children. Conversely, exposure to microbial diversity in the perinatal period may diminish the development of atopy and asthma symptoms.
背景
在过去几十年中，哮喘的患病率急剧上升。虽然遗传因素非常重要，但这种快速上升超过了基因组变异的速度。人们高度重视导致儿童哮喘的潜在可改变的早期生活暴露因素。
方法
我们查阅了近期医学文献，以获取有关围产期和儿童早期暴露因素以及儿童哮喘发病情况的重要研究。
结果与讨论
早期生活暴露于过敏原（屋尘螨（HDM）、有毛宠物、蟑螂、啮齿动物和霉菌）、空气污染（二氧化氮（NO₂）、臭氧（O₃）、挥发性有机化合物（VOCs）和颗粒物（PM））以及病毒性呼吸道感染（呼吸道合胞病毒（RSV）和人鼻病毒（hRV））与高危儿童哮喘的发生有关。相反，围产期接触微生物多样性可能会减少特应性和哮喘症状的发生。
Zotero 插件