Damera Gautam, Panettieri Reynold A
Translational Medicine, Respiratory, Inflammation, and Autoimmunity Group, MedImmune, LLC, Gaithersburg, Maryland, USA.
Allergy Asthma Proc. 2014 Mar-Apr;35(2):111-8. doi: 10.2500/aap.2013.34.3724.
Asthma, a syndrome manifested by airway inflammation and obstruction, globally contributes significantly to morbidity and mortality. Although current evidence identifies risk factors that evoke asthma, critical questions concerning susceptibility factors that induce severe persistent disease remain unclear. Early onset of asthma decreases lung function that may be unrecognized until later in adulthood when patients experience dyspnea on exertion and attenuated quality of life. This review highlights current evidence in predicting the onset of asthma and identifying those patients at greatest risk for severe persistent disease.
哮喘是一种以气道炎症和阻塞为特征的综合征，在全球范围内对发病率和死亡率有重大影响。尽管目前的证据已确定了引发哮喘的风险因素，但关于诱发严重持续性疾病的易感因素的关键问题仍不明确。哮喘的早期发作会降低肺功能，这种情况可能直到成年后期患者出现运动性呼吸困难和生活质量下降时才被发现。这篇综述重点介绍了目前在预测哮喘发作和识别那些患严重持续性疾病风险最高的患者方面的证据。
