Departamento de Ciências Veterinárias, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
Res Vet Sci. 2011 Oct;91(2):278-80. doi: 10.1016/j.rvsc.2011.01.001. Epub 2011 Jan 28.
Propofol total intravenous anesthesia should provide stability of the cardiovascular system. In this study, mean arterial pressure and heart rate were evaluated in eight healthy dogs anesthetized with increasing rates of propofol. The cerebral state index (CSI) was studied as an additional parameter. Although the estimated propofol plasma concentration reached a maximal value of 15.3 μg ml(-1), no hypotension or bradycardia were observed. Exploration of each animal's data revealed high inter-individual variability regarding mean arterial pressure and heart rate. Considering the logarithmic of the concentration, a moderate depressant effect of propofol on mean arterial pressure was revealed in five dogs but the effect was not followed on heart rate.
异丙酚全静脉麻醉应提供心血管系统的稳定性。在这项研究中，评估了 8 只健康犬在麻醉下使用异丙酚的递增率，以评估平均动脉压和心率。研究了脑状态指数（CSI）作为附加参数。尽管估计的异丙酚血浆浓度达到 15.3μgml(-1)的最大值，但未观察到低血压或心动过缓。对每个动物的数据进行探索表明，平均动脉压和心率的个体间变异性很大。考虑到浓度的对数，发现 5 只狗的异丙酚对平均动脉压有中等程度的抑制作用，但对心率没有影响。
