Chaturvedi R C, Rai R M, Sharma R K
Defence Institute of Physiology & Allied Sciences, Delhi Cantt.
Indian J Med Res. 1990 Dec;92:420-3.
The therapeutic role of carbogen was evaluated in subjects with sensorineural hearing loss by administering carbogen, a gas mixture of 95 per cent O2 and 5 per cent CO2, for seven consecutive days (30 min/day) and monitoring puretone audiometry before and after the administration. Significant improvement was observed both in air and bone conduction threshold levels on seventh day, indicating that there was some recoverable portion in the hearing level of these subjects. The improvement in hearing may be due to action of CO2 as an otic vasodilator coupled with supplementation of the O2 requirement of degenerating hair cells. Carbogen thus appears to be useful in persons with impaired hearing, involving the inner ear.
通过对感音神经性听力损失患者连续七天（每天30分钟）给予卡波金（一种由95%氧气和5%二氧化碳组成的混合气体）并监测给药前后的纯音听力测定，评估了卡波金的治疗作用。在第七天，气导和骨导阈值水平均有显著改善，表明这些受试者的听力水平存在一些可恢复的部分。听力的改善可能是由于二氧化碳作为耳血管扩张剂的作用，以及补充了退化毛细胞所需的氧气。因此，卡波金似乎对涉及内耳的听力受损者有用。
