Cinamon U, Bendet E, Kronenberg J
Department of Otolaryngology, Head and Neck Surgery, The Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel.
Eur Arch Otorhinolaryngol. 2001 Nov;258(9):477-80. doi: 10.1007/s004050100366.
There is no consensus regarding treatment modalities for idiopathic sudden sensorineural hearing loss (SNHL). In order to evaluate the effectiveness of steroid or carbogen inhalation therapies, a prospective double-blind placebo controlled study was designed. All 41 patients enrolled in the study had unilateral SNHL with no prior history of SNHL, otological pathological history or otoscopic findings. Patients were assigned to four treatment groups: prednisone tablets, placebo tablets, carbogen inhalation or room air inhalation. All were treated for 5 days. The audiometric data at admission was compared to that at day 6 and to data collected at follow-up (average 33 days). Results revealed no significant difference between the groups for early or late audiometric outcome. Age, time from onset of symptoms to initiation of treatment, tinnitus, audiogram configuration, and the presence of vertigo at onset did not significantly affect the outcome. The discrimination scores that were poor in all patient groups on admission improved within days in all groups. These findings suggest that steroids or carbogen inhalation have no therapeutic advantage over placebo. Also, regardless of treatment modality, hearing continued to improve for at least a month after treatment was stopped.
对于特发性突发性感音神经性听力损失（SNHL）的治疗方式尚无共识。为了评估类固醇或二氧化碳吸入疗法的有效性，设计了一项前瞻性双盲安慰剂对照研究。该研究纳入的41例患者均为单侧SNHL，且无前SNHL病史、耳科病理病史或耳镜检查结果。患者被分为四个治疗组：泼尼松片、安慰剂片、二氧化碳吸入或空气吸入。所有患者均接受5天治疗。将入院时的听力测定数据与第6天的数据以及随访时（平均33天）收集的数据进行比较。结果显示，各治疗组在早期或晚期听力测定结果方面无显著差异。年龄、症状出现至开始治疗的时间、耳鸣、听力图形态以及发病时是否存在眩晕均未对结果产生显著影响。所有患者组入院时较差的辨别分数在数天内均有所改善。这些发现表明，类固醇或二氧化碳吸入相对于安慰剂并无治疗优势。此外，无论采用何种治疗方式，停止治疗后听力至少持续改善一个月。
