Clinical Research Center, National Nagasaki Medical Center, Omura City, Nagasaki, Japan.
Med Sci Monit. 2011 Feb;17(2):PH7-11. doi: 10.12659/msm.881375.
The incidence of hepatocellular carcinoma (HCC) in Japan has still been increasing. The aim of the present study was to analyze the epidemiological trend of HCC in the western area of Japan, Kyushu.
MATERIAL/METHODS: A total of 10,010 patients with HCC diagnosed between 1996 and 2008 in the Liver Cancer study group of Kyushu (LCSK), were recruited for this study. Cohorts of patients with HCC were categorized into five year intervals. The etiology of HCC was categorized to four groups as follows; B: HBsAg positive, HCV-RNA negative, C: HCV-RNA positive, HBsAg negative, B+C: both of HBsAg and HCV-RNA positive, nonBC: both of HBsAg and HCV-RNA negative.
B was 14.8% (1,485 of 10,010), whereas 68.1% (6,819 of 10,010) had C, and 1.4% (140 of 10,010) had HCC associated with both viruses. The remaining 1,566 patients (15.6%) did not associate with both viruses.
Cohorts of patients with HCC were divided into six-year intervals (1996-2001 and 2002-2007). The ratio of C cases decreased from 73.1% in 1996-2001 to 64.9% in 2002-2007. On the other hand, B and -nonBC cases increased significantly from 13.9% and 11.3% in 1996-2001 to 16.2% and 17.6% in 2002-2007, respectively.
The incidence of hepatocellular carcinoma associated with hepatitis C infection decreased after 2001 in Kyushu area. This change was due to the increase in the number and proportion of the HCC not only nonBC patients but also B patients.
日本肝细胞癌（HCC）的发病率仍在上升。本研究的目的是分析日本九州西部地区 HCC 的流行病学趋势。
材料/方法：本研究共纳入了 1996 年至 2008 年期间在九州肝癌研究组（LCSK）诊断为 HCC 的 10010 例患者。将 HCC 患者分为五个五年期队列。HCC 的病因分为以下四组：B：HBsAg 阳性，HCV-RNA 阴性，C：HCV-RNA 阳性，HBsAg 阴性，B+C：HBsAg 和 HCV-RNA 均阳性，非 BC：HBsAg 和 HCV-RNA 均阴性。
B 组占 14.8%（1485/10010），68.1%（6819/10010）为 C 组，1.4%（140/10010）为同时感染两种病毒的 HCC。其余 1566 例患者（15.6%）与两种病毒均无关联。
将 HCC 患者分为六年期队列（1996-2001 年和 2002-2007 年）。C 组病例比例从 1996-2001 年的 73.1%降至 2002-2007 年的 64.9%。另一方面，B 组和非 BC 组病例显著增加，从 1996-2001 年的 13.9%和 11.3%分别增加至 2002-2007 年的 16.2%和 17.6%。
2001 年后，九州地区丙型肝炎感染相关肝细胞癌的发病率下降。这种变化是由于不仅非 BC 患者而且 B 患者的 HCC 数量和比例增加所致。
