Roch-Arveiller M, Legros R, Chanaud B, Muntaner O, Strzalko S, Thuret A, Willoughby D A, Giroud J P
Département de Pharmacologie, CNRS UA 595, Paris, France.
Biomed Pharmacother. 1990;44(9):467-74. doi: 10.1016/0753-3322(90)90207-p.
Various inflammatory reactions can be induced by different crystals responsible for various arthropathies. The aim of this work was to study modifications induced in the rat, locally and at distance, by intrapleural injection of 3 forms of pyrophosphate crystals (CaPP dihydrated monoclinic (M), CaPP dihydrated triclinic (T) and CaPP anhydrous (beta]. The data presented here show that the structure of irritants plays a decisive role in the kinetics of inflammatory reactions from a local and systemic point of view.
多种导致不同关节病的晶体可引发各种炎症反应。本研究的目的是通过向大鼠胸膜腔内注射三种形式的焦磷酸盐晶体（二水合单斜晶型（M）、二水合三斜晶型（T）和无水型（β）），研究局部和远处所引起的变化。此处呈现的数据表明，从局部和全身角度来看，刺激物的结构在炎症反应动力学中起着决定性作用。
