Davis H L, von Hoff D D, Henney J E, Rozencweig M
Recent Results Cancer Res. 1978;63:21-9. doi: 10.1007/978-3-642-81219-4_2.
The antitumor antibiotics have thus made a major impact on oncologic practice. The continued search for productive strains of these organisms should be encouraged. In addition, the activity and toxicity spectrum suggests the need for vigorous analog development. An active anthracycline devoid of cardiotoxicity; a bleomycin with no effect on pulmonary tissue; an analog of streptozotocin devoid of nephrotoxicity; these would be advances of inestimable benefit to the cancer patient of the future.
因此，抗肿瘤抗生素对肿瘤治疗实践产生了重大影响。应鼓励继续寻找这些生物体的高产菌株。此外，其活性和毒性谱表明需要大力开展类似物研发。一种无心脏毒性的活性蒽环类药物；一种对肺组织无影响的博来霉素；一种无肾毒性的链脲佐菌素类似物；这些将是对未来癌症患者有不可估量益处的进展。
