Mehta Mitul A, O'Daly Owen G
Institute of Psychiatry at King's College London, Centre for Neuroimaging Sciences (PO89), London, SE5 8AF, UK.
Methods Mol Biol. 2011;711:551-65. doi: 10.1007/978-1-61737-992-5_28.
Magnetic resonance imaging (MRI) allows the assessment of functional changes consequent to drug administration. Two main approaches have been used: changes in functional MRI signal following drug injection compared to the signal prior to injection and changes in task-related brain networks on drug compared to placebo. Here we describe the additional constraints drug studies place on subject selection, study designs and additional technical requirements. Critical issues in the design of statistical analysis routines are described, including the incorporation of peripheral markers of drug action, such as heart and respiration rate, as well as pharmacokinetic data. Finally, we address methods to minimise the potential influence of non-specific drug effects and side effects on the MRI signal allowing interpretation more closely aligned to the precise research questions.
磁共振成像（MRI）能够评估药物给药后产生的功能变化。主要使用了两种方法：与注射药物前的信号相比，注射药物后功能MRI信号的变化；与安慰剂相比，药物作用下与任务相关的脑网络的变化。在此，我们描述了药物研究对受试者选择、研究设计和其他技术要求所带来的额外限制。阐述了统计分析程序设计中的关键问题，包括纳入药物作用的外周标志物，如心率和呼吸率，以及药代动力学数据。最后，我们探讨了将非特异性药物效应和副作用对MRI信号的潜在影响降至最低的方法，以使解释更紧密地符合精确的研究问题。
