Guha Santanu, Pande Arindam, Mookerjee Soura, Bhattacharya Rabindra, Pain Shantasil, Karmakar Rathindra Nath, Mani Siddhartha, Bhattacharya Raja, Biswas Anirban, Saha Sandip, Deb P K
Department of Cardiology, Medical College Kolkata, West Bengal, India.
Indian Heart J. 2010 Jul-Aug;62(4):330-4.
Cardiac affection in human iummunodeficiency virus (HIV) infection is a recognized entity. Some form of heart disease is demonstrable at autopsy in approximately 40 percent of cases and by echocardiography in approximately 25 percent of patients with HIV. the studies indicate that cardiac involvements associated with HIV are mainly characterized by cardiomyopathy and pericardial disease. HIV infection is a global pandemic which is also rapidly spreading in india. We conducted the study to have some insight into the profile oflndian patients.
MATERIAL & METHODS: In this cross sectional hospital based study, we evaluated immunological (CD4 count) and echocardiographic status of 45 asymptomatic HIV seropositive patients who did not receive anti-retroviral therapy. The results were compared with age and sex matched controls. Statistical analysis was done using appropriate statistical methods.
Most common cardiovascular abnormalities were diastolic dysfunction (18%) followed by pericardial effusion (13%) and systolic dysfunction (7%). When compared with controls the study population had statistically higher number of diastolic dysfunction (p value = 0.035) but not systolic dysfunction (p value = 0.61); none of the control population was having pericardial effusion. Low CD4 count was significantly associated with pericardial effusion (p value 0.048) but the association with diastolic dysfunction (p value = 0.46) or systolic dysfunction (p value = 0.84) was not statistically significant.
Cardiovascular complications are common among HIV infected patients in india, most common being diastolic dysfunction and pericardial effusion. Low CD4 counts are associated significantly with pericardial effusion. These abnormalities are likely to be found with greater frequency in clinical practice as management of opportunistic infections continues to improve.
人类免疫缺陷病毒（HIV）感染中的心脏病变是一个公认的实体。在大约40%的病例尸检中可发现某种形式的心脏病，在大约25%的HIV患者中通过超声心动图可检测到。研究表明，与HIV相关的心脏受累主要表现为心肌病和心包疾病。HIV感染是一种全球大流行疾病，在印度也迅速蔓延。我们进行这项研究以深入了解印度患者的情况。
在这项基于医院的横断面研究中，我们评估了45例未接受抗逆转录病毒治疗的无症状HIV血清阳性患者的免疫学（CD4计数）和超声心动图状况。将结果与年龄和性别匹配的对照组进行比较。使用适当的统计方法进行统计分析。
最常见的心血管异常是舒张功能障碍（18%），其次是心包积液（13%）和收缩功能障碍（7%）。与对照组相比，研究人群中舒张功能障碍的数量在统计学上更高（p值 = 0.035），但收缩功能障碍并非如此（p值 = 0.61）；对照组中无人有心包积液。低CD4计数与心包积液显著相关（p值0.048），但与舒张功能障碍（p值 = 0.46）或收缩功能障碍（p值 = 0.84）的关联在统计学上不显著。
在印度，HIV感染患者中心血管并发症很常见，最常见的是舒张功能障碍和心包积液。低CD4计数与心包积液显著相关。随着机会性感染管理的持续改善，这些异常在临床实践中可能会更频繁地被发现。
