HIV阳性患者的心脏异常：印度一项观察性研究的结果

Cardiac abnormalities in HIV-positive patients: results from an observational study in India.

作者信息

Jain Nirdesh, Reddy Dandu H, Verma Shailendra Prasad, Khanna Roopali, Vaish Arvind Kumar, Usman Kauser, Tripathi Anil Kumar, Singh Abhishek, Mehrotra Sanjay, Gupta Alok

机构信息

Department of Internal Medicine, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India.

出版信息

J Int Assoc Provid AIDS Care. 2014 Jan-Feb;13(1):40-6. doi: 10.1177/1545109712456740. Epub 2012 Sep 11.

DOI:10.1177/1545109712456740

PMID:22968352

Abstract

BACKGROUND

The clinical presentation of cardiac abnormalities in HIV-infected patients may be atypical or masked by concurrent illnesses that lead to misdiagnosis or they remain undiagnosed; therefore, this study was aimed to determine the frequency of cardiac abnormalities in HIV-infected patients.

MATERIAL AND METHODS

Consecutive HIV-infected patients of age >13 years were studied for 3 months, after obtaining their consent. After clinical assessment, chest x-ray, electrocardiogram, 2-dimensional echocardiography and serum Troponin T levels were done.

RESULTS

A total of 100 patients were studied, cardiomegaly was observed in the x-ray of 15% of them, abnormal electrocardiogram was seen in 18%, 2-dimensional echocardiography was abnormal in 67%; and diastolic dysfunction (42.8%) was the commonest abnormality followed by dilated cardiomyopathy (17.6%). Serum troponin T was elevated in 8%. The variables, opportunistic infections (OIs), antiretroviral therapy (ART), stage of HIV disease, and CD4 counts, did not affect the frequency of diastolic dysfunction.

CONCLUSION

The diastolic dysfunction is the most common cardiac abnormality observed in HIV-infected patients.

摘要

背景

HIV感染患者心脏异常的临床表现可能不典型，或被并发疾病掩盖，从而导致误诊或仍未被诊断出来；因此，本研究旨在确定HIV感染患者心脏异常的发生率。

材料与方法

在获得年龄大于13岁的连续HIV感染患者同意后，对其进行了3个月的研究。经过临床评估后，进行了胸部X光、心电图、二维超声心动图检查及血清肌钙蛋白T水平检测。

结果

共研究了100例患者，其中15%的患者X光显示心脏扩大，18%的患者心电图异常，67%的患者二维超声心动图异常；舒张功能障碍（42.8%）是最常见的异常，其次是扩张型心肌病（17.6%）。8%的患者血清肌钙蛋白T升高。机会性感染（OIs）、抗逆转录病毒治疗（ART）、HIV疾病阶段及CD4细胞计数等变量并不影响舒张功能障碍的发生率。