Product Safety Center, Monsanto Company, 800 North Lindbergh Boulevard, St. Louis, Missouri 63167, USA.
J Agric Food Chem. 2011 Jun 8;59(11):5865-76. doi: 10.1021/jf103874t. Epub 2011 Jan 31.
Compositional analysis is an important tool in the evaluation of the safety and nutritional status of biotechnology-derived crops. As part of the comparative assessment of a biotechnology-derived crop, its composition is evaluated by quantitative measurement of the levels of key nutrients, antinutrients, and secondary metabolites and compared to that of conventional crops. To evaluate the effect of combining multiple biotech traits through conventional breeding, the forage and grain compositions of the double combinations MON 810 × NK603, MON 863 × MON 810, and MON 863 × NK603 and the triple combination MON 863 × NK603 × MON 810 were compared to their respective near-isogenic, conventional control hybrids. Overall, a total of 241 statistical comparisons between the multitrait biotechnology crop and its corresponding conventional controls were conducted. Of these comparisons 192 (79.7%) were not statistically significantly different (p > 0.05), and all 49 of the differences were within the 99% tolerance interval for commercial hybrids grown in the same field or related field trials. These data on combined trait biotechnology-derived products demonstrated that the forage and grain were compositionally equivalent to their conventional comparators, indicating the absence of any influence of combining insect protection and herbicide tolerance traits by conventional breeding on compositional variation.
成分分析是评估生物技术衍生作物安全性和营养状况的重要工具。作为生物技术衍生作物比较评估的一部分，通过定量测量关键营养素、抗营养物质和次生代谢物的水平来评估其成分，并与常规作物进行比较。为了评估通过常规育种组合多个生物技术特性的效果，对 MON 810×NK603、MON 863×MON 810 和 MON 863×NK603 的饲料和谷物成分以及 MON 863×NK603×MON 810 的三倍体组合进行了比较与各自的近等基因、常规对照杂种。总体而言，对多性状生物技术作物及其相应的常规对照进行了总共 241 次统计比较。其中 192 次（79.7%）没有统计学差异（p＞0.05），所有 49 次差异均在同一田间或相关田间试验中种植的商业杂种的 99%容忍区间内。这些关于组合性状生物技术衍生产品的数据表明，饲料和谷物在成分上与常规对照物相当，表明常规育种中结合昆虫保护和除草剂耐受性特性不会对成分变化产生任何影响。
