Dresden University of Technology, Medical Faculty Carl Gustav Carus, Clinical Sensoring and Monitoring, University Hospital, Department of Neurosurgery, 01307 Dresden, Germany.
J Biomed Opt. 2011 Jan-Feb;16(1):016001. doi: 10.1117/1.3528011.
A new approach to cortical perfusion imaging is demonstrated using high-sensitivity thermography in conjunction with multivariate statistical data analysis. Local temperature changes caused by a cold bolus are imaged and transferred to a false color image. A cold bolus of 10 ml saline at ice temperature is injected systemically via a central venous access. During the injection, a sequence of 735 thermographic images are recorded within 2 min. The recorded data cube is subjected to a principal component analysis (PCA) to select slight changes of the cortical temperature caused by the cold bolus. PCA reveals that 11 s after injection the temperature of blood vessels is shortly decreased followed by an increase to the temperature before the cold bolus is injected. We demonstrate the potential of intraoperative thermography in combination with multivariate data analysis to image cortical cerebral perfusion without any markers. We provide the first in vivo application of multivariate thermographic imaging.
一种新的皮质灌注成像方法通过高灵敏度热成像与多元统计数据分析相结合来实现。通过注射冷弹丸引起的局部温度变化被成像并转换为假彩色图像。通过中心静脉通路向体内系统地注射 10 毫升盐水的冷弹丸。在注射过程中，在 2 分钟内记录 735 个热成像图像序列。记录的数据体进行主成分分析（PCA）以选择冷弹丸引起的皮质温度的轻微变化。PCA 显示，在注射后 11 秒，血管温度短暂下降，随后升高至注射冷弹丸之前的温度。我们展示了术中热成像与多元数据分析相结合在没有任何标记的情况下对皮质脑灌注进行成像的潜力。我们提供了多元热成像的首次体内应用。
