Bengal Institute of Pharmaceutical Sciences, Kalyani, Nadia, India.
Pharm Biol. 2011 Apr;49(4):335-40. doi: 10.3109/13880209.2010.516755. Epub 2011 Feb 1.
Terminalia arjuna Roxb. (Combretaceae), commonly known as Arjuna, is a large tree grown throughout the Indian peninsula and used traditionally for several medicinal purposes.
To evaluate antihyperglycemic and antioxidant role of methanol extract of T. arjuna leaf (META) in Wistar rats.
Hyperglycemia was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with META orally at the dose of 100 and 200 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every fifth day during the 15-day treatment. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), cholesterol, and total protein were estimated. Antioxidant properties were assessed by estimating hepatic lipid peroxidation, reduced glutathione (GSH), and catalase (CAT).
META at the dose of 100 and 200 mg/kg orally significantly (P < 0.001) and dose-dependently reduced and normalized blood glucose levels as compared with that of STZ control group. Serum biochemical parameters were significantly (P < 0.001) restored toward normal levels in META-treated rats as compared with STZ control. META treatment also significantly (P < 0.001) decreased lipid peroxidation and recovered GSH level and CAT activity toward normal as compared with STZ control.
The present study infers that T. arjuna leaf demonstrated remarkable antihyperglycemic activity in STZ-induced diabetic rats. The potential antihyperglycemic action is plausibly due to its underlying antioxidant role.
Terminalia arjuna Roxb.（使君子科），俗称 Arjuna，是一种在整个印度半岛生长的大树，传统上用于多种药用目的。
评估 Terminalia arjuna 叶甲醇提取物（META）在 Wistar 大鼠中的降血糖和抗氧化作用。
通过单次腹腔注射链脲佐菌素（STZ，65mg/kg 体重）诱导大鼠高血糖。STZ 诱导后 3 天，用 META 以 100 和 200mg/kg 体重的剂量口服治疗高血糖大鼠，每天一次，共 15 天。格列本脲（0.5mg/kg，口服）用作参考药物。在 15 天的治疗过程中，每第五天测量空腹血糖水平。测定血清生化参数，如血清谷氨酸丙酮酸转氨酶（SGPT）、血清谷氨酸草酰乙酸转氨酶（SGOT）、碱性磷酸酶（ALP）、胆固醇和总蛋白。通过测定肝脂质过氧化、还原型谷胱甘肽（GSH）和过氧化氢酶（CAT）来评估抗氧化特性。
META 以 100 和 200mg/kg 体重的剂量口服给药可显著（P<0.001）和剂量依赖性地降低和正常化与 STZ 对照组相比，血糖水平。与 STZ 对照组相比，META 治疗的大鼠血清生化参数也显著（P<0.001）恢复正常水平。META 治疗还显著（P<0.001）降低了脂质过氧化作用，并恢复了 GSH 水平和 CAT 活性至正常水平。
本研究推断，Terminalia arjuna 叶在 STZ 诱导的糖尿病大鼠中表现出显著的降血糖活性。潜在的降血糖作用可能与其潜在的抗氧化作用有关。
