Patra Susmita, Bhattacharya Sanjib, Bala Asis, Haldar Pallab Kanti
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
West Bengal Medical Services Corporation Ltd., Kolkata, West Bengal, India.
J Adv Pharm Technol Res. 2020 Jan-Mar;11(1):44-52. doi: 10.4103/japtr.JAPTR_98_19.
(Caryophyllaceae), commonly known as in Sikkimese-Tibetan, is a creeping herb grown in tropical and subtropical regions of the world. It is used by ethnic groups of Sikkim, North-East India, for the treatment of various diseases including diabetes. This study aimed to investigate the antidiabetic effect of methanol extract from leaf (DCME) in streptozotocin (STZ) and nicotinamide (NA)-induced type 2 diabetes in rats. Diabetic Wistar albino rats were treated with DCME at 200 mg/kg and 400 mg/kg orally for 28 days. Metformin (150 mg/kg b.w.) was used as a reference drug. Fasting blood glucose (FBG) level; serum biochemical parameters; and liver, kidney, and antioxidant parameters were estimated, and pancreatic histopathology was performed after 28 days of treatment. Administration of DCME to STZ-NA-induced diabetic rats at 200 mg/kg and 400 mg/kg orally for 28 days exhibited statistically significant ( < 0.05) and dose-dependent reduction of FBG, glycosylated hemoglobin, serum lipid, and hepatorenal antioxidative parameters in DCME-treated groups when compared to those of diabetic controls. Histopathological studies of pancreas in DCME-treated rats showed improvement in β-cell density compared to diabetic group. The results demonstrate the significant antidiabetic potential of leaf in albino rats plausibly by reducing oxidative stress and serum lipids levels, justifying the folkloric use of this plant in the treatment of diabetes.
石竹科（Caryophyllaceae），在锡金 - 藏语中俗称……，是一种生长在世界热带和亚热带地区的匍匐草本植物。印度东北部锡金邦的少数民族用它来治疗包括糖尿病在内的各种疾病。本研究旨在探讨来自……叶的甲醇提取物（DCME）对链脲佐菌素（STZ）和烟酰胺（NA）诱导的大鼠2型糖尿病的抗糖尿病作用。将糖尿病Wistar白化大鼠分别以200 mg/kg和400 mg/kg的剂量口服DCME，持续28天。二甲双胍（150 mg/kg体重）用作参比药物。在治疗28天后，测定空腹血糖（FBG）水平、血清生化参数、肝脏、肾脏和抗氧化参数，并进行胰腺组织病理学检查。与糖尿病对照组相比，以200 mg/kg和400 mg/kg的剂量口服DCME 28天的STZ - NA诱导的糖尿病大鼠，其FBG、糖化血红蛋白、血清脂质和肝肾抗氧化参数均呈现出具有统计学意义（P < 0.05）的剂量依赖性降低。与糖尿病组相比，DCME治疗大鼠胰腺的组织病理学研究显示β细胞密度有所改善。结果表明，……叶通过降低氧化应激和血清脂质水平，对白化大鼠具有显著的抗糖尿病潜力，证明了该植物在治疗糖尿病方面的民间用途是合理的。
