甘草（Glycyrrhiza glabra L.）叶的植物复合物 - 化学特征及其抗氧化、抗遗传毒性和抗炎活性评价。

Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves--chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity.

机构信息

Istituto del C.N.R. di Chimica Biomolecolare, Via Paolo Gaifami, 18 I-95126 Catania, Italy.

出版信息

Fitoterapia. 2011 Jun;82(4):546-56. doi: 10.1016/j.fitote.2011.01.009. Epub 2011 Jan 31.

DOI:10.1016/j.fitote.2011.01.009

Abstract

Three extracts of different polarities of Glycyrrhiza glabra L. leaves were characterized and evaluated for their antioxidant, anti-genotoxic and anti-inflammatory activity. In total, thirty components have been identified and quantified through the use of liquid chromatography (LC) with ultraviolet-visible diode-array-detector (UV-vis-DAD) and mass spectrometry (MS). The main components belong to the polyphenols family, being flavonoid and dihydrostilbene derivatives. The extracts have been investigated for their antioxidant, anti-genotoxic and anti-inflammatory activities, which are fundamental requirements of efficacious chemo-preventive agents. The ethyl acetate extract proved to be the most valuable, evidently for the conspicuous presence of several polyphenols, namely flavonoids and dihydrostilbenes.

摘要

甘草叶的三种不同极性提取物的特征和评价，评估其抗氧化、抗基因毒性和抗炎活性。通过使用带有紫外可见二极管阵列检测器（UV-vis-DAD）和质谱（MS）的液相色谱（LC），总共鉴定和定量了三十种成分。主要成分属于多酚类家族，是黄酮类和二氢芪类衍生物。提取物的抗氧化、抗基因毒性和抗炎活性已被研究，这是有效化学预防剂的基本要求。乙酸乙酯提取物被证明是最有价值的，显然是因为几种多酚类物质的明显存在，即黄酮类和二氢芪类。