Division of Endocrinology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210 Street, Bronx, NY 10467, USA.
Med Clin North Am. 2011 Mar;95(2):309-25, vii. doi: 10.1016/j.mcna.2010.11.004.
Although the state of prediabetes is defined by its role as a diabetes risk factor, it also carries a significant risk of cardiovascular disease, independent of progression to diabetes. Typical diabetic microvascular complications also occur, albeit at low rates, in prediabetes. There is evidence that both glucose-related and glucose-independent mechanisms contribute to these vascular complications. Effective preventive strategies will likely require control of glycemia, as well as other metabolic risk factors. This article reviews some of the proposed mechanisms for the vascular complications of the prediabetic state.
尽管糖尿病前期的状态是通过其作为糖尿病风险因素来定义的，但它也存在着显著的心血管疾病风险，且与进展为糖尿病无关。典型的糖尿病微血管并发症也会发生，尽管发生率较低，但在糖尿病前期。有证据表明，葡萄糖相关和非葡萄糖相关的机制都有助于这些血管并发症的发生。有效的预防策略可能需要控制血糖，以及其他代谢危险因素。本文回顾了一些糖尿病前期状态下血管并发症的潜在机制。
