改变 T 细胞受体信号在过敏性疾病发病机制中的作用。
Altered T-cell receptor signaling in the pathogenesis of allergic disease.
机构信息
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
出版信息
J Allergy Clin Immunol. 2011 Feb;127(2):351-4. doi: 10.1016/j.jaci.2010.11.033.
Abstract
Mounting evidence from animal models has demonstrated that alterations in T-cell receptor (TCR) signaling alone can lead to dramatically skewed differentiation of naive T cells into T(H)2 cells, to T(H)2 effector functions, and to T(H)2-related diseases. There is significant potential relevance of these observations to human disease. Specifically, a number of immunodeficiencies associated with atopic disease might have atopy as a manifestation because of aberrant TCR signaling. It is therefore important to attempt to identify a role for defects in TCR signaling in the pathogenesis of common atopic diseases.
摘要
越来越多的动物模型研究表明，T 细胞受体 (TCR) 信号的改变单独作用就可以导致初始 T 细胞极向分化为 T(H)2 细胞，并获得 T(H)2 效应功能，从而导致 T(H)2 相关疾病。这些观察结果与人类疾病有很大的相关性。具体来说，一些与特应性疾病相关的免疫缺陷可能由于 TCR 信号的异常而表现出特应性。因此，尝试确定 TCR 信号缺陷在常见特应性疾病发病机制中的作用非常重要。
相似文献
1
Altered T-cell receptor signaling in the pathogenesis of allergic disease.改变 T 细胞受体信号在过敏性疾病发病机制中的作用。
J Allergy Clin Immunol. 2011 Feb;127(2):351-4. doi: 10.1016/j.jaci.2010.11.033.
2
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.信号转导衔接蛋白p62是辅助性T细胞2功能和过敏性气道炎症的重要介质。
EMBO J. 2006 Aug 9;25(15):3524-33. doi: 10.1038/sj.emboj.7601250. Epub 2006 Jul 27.
3
TCR-dependent translational control of GATA-3 enhances Th2 differentiation.TCR 依赖性 GATA-3 翻译调控增强 Th2 细胞分化。
J Immunol. 2010 Sep 15;185(6):3209-16. doi: 10.4049/jimmunol.0902544. Epub 2010 Aug 9.
4
'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation.“总而言之”：从前体细胞到效应激活的 T 辅助型 2 细胞分化的转录调控。
Immunology. 2013 Sep;140(1):31-8. doi: 10.1111/imm.12121.
5
Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy.通过 CARD11 降低 T 细胞受体信号传导，导致过敏的差异在于破坏叉头框蛋白 3 阳性调节细胞与 T(H)2 效应细胞。
J Allergy Clin Immunol. 2011 May;127(5):1277-85.e5. doi: 10.1016/j.jaci.2010.12.1081. Epub 2011 Feb 12.
6
TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease.人类 Th2 相关特应性疾病中的 TCR 信号异常。
Front Immunol. 2018 Apr 16;9:719. doi: 10.3389/fimmu.2018.00719. eCollection 2018.
7
Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling.SLAP的SH3和SH2结构域在细胞内细胞质特异性递送可抑制T细胞受体介导的信号传导。
Biochem Biophys Res Commun. 2015 May 8;460(3):603-8. doi: 10.1016/j.bbrc.2015.03.076. Epub 2015 Mar 20.
8
Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.TCR信号的强度决定了Th1和Th2 CD4 + T细胞分化所需的共刺激条件。
J Immunol. 1997 Dec 15;159(12):5956-63.
9
Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease.DENND1B 在 TH2 细胞和过敏性疾病中对 T 细胞受体信号的调节。
Cell. 2016 Jan 14;164(1-2):141-155. doi: 10.1016/j.cell.2015.11.052. Epub 2016 Jan 7.
10
Dual effects of Sprouty1 on TCR signaling depending on the differentiation state of the T cell.根据T细胞的分化状态，Sprouty1对TCR信号传导具有双重作用。
J Immunol. 2006 May 15;176(10):6034-45. doi: 10.4049/jimmunol.176.10.6034.
引用本文的文献
1
Expanding spectrum, intrafamilial diversity, and therapeutic challenges from 15 patients with heterozygous CARD11-associated diseases: A single center experience.15 例杂合性 CARD11 相关疾病患者的谱扩展、家系内多样性和治疗挑战：单中心经验。
Front Immunol. 2022 Nov 3;13:1020927. doi: 10.3389/fimmu.2022.1020927. eCollection 2022.
2
Exploration of the Molecular Mechanism of FUZI (Aconiti Lateralis Radix Praeparata) in Allergic Rhinitis Treatment Based on Network Pharmacology.基于网络药理学探讨附子（制川乌）治疗过敏性鼻炎的分子机制。
Med Sci Monit. 2020 Mar 1;26:e920872. doi: 10.12659/MSM.920872.
3
Germline hypomorphic CARD11 mutations in severe atopic disease.严重特应性疾病中的种系低表达CARD11突变
Nat Genet. 2017 Aug;49(8):1192-1201. doi: 10.1038/ng.3898. Epub 2017 Jun 19.
4
FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.FOXP3 + 调节性T细胞需要WASP来抑制Th2介导的食物过敏。
J Clin Invest. 2016 Oct 3;126(10):4030-4044. doi: 10.1172/JCI85129. Epub 2016 Sep 19.
5
Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.对花生过敏的学龄前儿童进行早期口服免疫疗法是安全且高效的。
J Allergy Clin Immunol. 2017 Jan;139(1):173-181.e8. doi: 10.1016/j.jaci.2016.05.027. Epub 2016 Aug 10.
6
Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis.皮肤炎症性疾病：特应性皮炎的分子机制
Int J Mol Sci. 2016 Jul 30;17(8):1234. doi: 10.3390/ijms17081234.
7
Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection.与人类种群扩张相关的选择压力变化，可能解释了因正选择特征而富集的代谢和免疫相关途径。
BMC Genomics. 2016 Jul 21;17:504. doi: 10.1186/s12864-016-2783-2.
8
Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.黏着斑激酶负调控 T 细胞抗原受体下游的 Lck 功能。
J Immunol. 2013 Dec 15;191(12):6208-21. doi: 10.4049/jimmunol.1301587. Epub 2013 Nov 13.
9
Elevated IgE and atopy in patients treated for early-onset ADA-SCID.接受早发型ADA - SCID治疗的患者中IgE升高与特应性反应
J Allergy Clin Immunol. 2013 Dec;132(6):1444-6. doi: 10.1016/j.jaci.2013.05.040. Epub 2013 Jul 26.
10
The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases.杯满则溢：原发性免疫缺陷病不断增多带来的启示。
Nat Rev Immunol. 2013 Sep;13(9):635-48. doi: 10.1038/nri3493. Epub 2013 Jul 26.
本文引用的文献
1
Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production.前沿：多克隆 CD4+ 反应中缺乏高亲和力的肽竞争，揭示了 IL-4 的产生。
J Immunol. 2010 Jun 15;184(12):6569-73. doi: 10.4049/jimmunol.1000674. Epub 2010 May 21.
2
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.Dock8突变会损害B细胞免疫突触、生发中心和长寿抗体的产生。
Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820. Epub 2009 Nov 8.
3
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.白细胞介素-17A和-17F的差异表达通过诱导性T细胞激酶与T细胞受体信号传导相关联。
Immunity. 2009 Oct 16;31(4):587-97. doi: 10.1016/j.immuni.2009.07.009. Epub 2009 Oct 8.
4
Combined immunodeficiency associated with DOCK8 mutations.与DOCK8突变相关的联合免疫缺陷
N Engl J Med. 2009 Nov 19;361(21):2046-55. doi: 10.1056/NEJMoa0905506. Epub 2009 Sep 23.
5
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.LAT衔接蛋白的缺失会将抗原反应性T细胞转变为独立于T细胞受体发挥作用的致病性效应细胞。
Immunity. 2009 Aug 21;31(2):197-208. doi: 10.1016/j.immuni.2009.05.013. Epub 2009 Aug 13.
6
Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses.ω-1是一种由曼氏血吸虫卵分泌的糖蛋白，可驱动Th2反应。
J Exp Med. 2009 Aug 3;206(8):1673-80. doi: 10.1084/jem.20082460. Epub 2009 Jul 27.
7
The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1).血吸虫卵中负责使树突状细胞向Th2极化的主要成分是一种T2核糖核酸酶（ω-1）。
J Exp Med. 2009 Aug 3;206(8):1681-90. doi: 10.1084/jem.20082462. Epub 2009 Jul 27.
8
Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity.人类中ZAP70的亚效突变会导致迟发性免疫缺陷，且不会引发自身免疫。
Eur J Immunol. 2009 Jul;39(7):1966-76. doi: 10.1002/eji.200939385.
9
Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome.人类T细胞发育的早期缺陷严重影响胸腺基质细胞的分布和成熟：对奥门综合征病理生理学的可能影响。
Blood. 2009 Jul 2;114(1):105-8. doi: 10.1182/blood-2009-03-211029. Epub 2009 May 4.
10
Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.自身抗原表位的可及性控制TCR转基因自身免疫性胃炎的表型、严重程度和外显率。
Eur J Immunol. 2008 Dec;38(12):3339-53. doi: 10.1002/eji.200838584.
Zotero 插件