Department of Family Medicine, Poznań University of Medical Sciences, Przybyszewskiego St 49, 60-533 Poznan, Poland.
Arch Gerontol Geriatr. 2011 Sep-Oct;53(2):e237-42. doi: 10.1016/j.archger.2011.01.002. Epub 2011 Feb 1.
Despite known positive association between body mass and bone mineral density (BMD), relative contribution of fat and lean tissue to BMD remains under debate. We aimed at investigating the effect of selected anthropometric parameters, including fat content and lean body mass (LBM) on BMD in postmenopausal, osteoporotic women with body mass index (BMI) > 20 kg/m(2). The study involved 92 never-treated women (mean age 69.5 ± 7.3). L1-L4 and femoral neck (FN) BMD were measured by dual energy X-ray absorptiometry (DEXA). Absolute (kg) and relative (%) fat and LBM were assessed by means of electric bioimpedance method. We showed both FN and L1-L4 BMD were positively correlated with body mass, waist circumference (WC), hip circumference (HC) and LBM (kg). Fat content correlated with FN BMD (r = 0.36, p < 0.001). Regression analysis revealed the only predictor of L1-L4 BMD was LBM (R(2) = 0.18, p < 0.05), for FN--both LBM and fat (R(2) = 0.18, p < 0.05 and p < 0.001, respectively). Of the women, 44.5% were overweight, 18.4% obese. Obese women displayed the highest BMD. Both L1-L4 and FN BMD were higher in women with WC > 80 cm. In postmenopausal osteoporotic women with BMI > 20 kg/m(2) both fat and lean tissue might contribute to BMD. Positive association between body mass and BMD does not make obesity and osteoporosis mutually exclusive.
尽管体重与骨密度（BMD）之间存在已知的正相关关系，但脂肪和瘦组织对 BMD 的相对贡献仍存在争议。我们旨在研究包括脂肪含量和瘦体重（LBM）在内的选定人体测量参数对 BMI>20 kg/m²的绝经后骨质疏松女性 BMD 的影响。该研究涉及 92 名未经治疗的女性（平均年龄 69.5±7.3 岁）。L1-L4 和股骨颈（FN）BMD 通过双能 X 射线吸收法（DEXA）测量。通过电阻抗法评估绝对（kg）和相对（%）脂肪和 LBM。我们表明 FN 和 L1-L4 BMD 与体重、腰围（WC）、臀围（HC）和 LBM（kg）呈正相关。脂肪含量与 FN BMD 相关（r=0.36，p<0.001）。回归分析显示，L1-L4 BMD 的唯一预测因子是 LBM（R²=0.18，p<0.05），对于 FN--LBM 和脂肪都是（R²=0.18，p<0.05 和 p<0.001）。在这些女性中，44.5%超重，18.4%肥胖。肥胖女性的 BMD 最高。WC>80cm 的女性 L1-L4 和 FN BMD 更高。在 BMI>20 kg/m²的绝经后骨质疏松女性中，脂肪和瘦组织可能都有助于 BMD。体重与 BMD 之间的正相关关系并不使肥胖症和骨质疏松症相互排斥。
