调整体重和去脂体重的静态机械负荷后，肥胖与骨质疏松之间的不同相关性。
The different correlations between obesity and osteoporosis after adjustment of static mechanical loading from weight and fat free mass.
机构信息
Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, P. R. China.
Department of Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
出版信息
J Musculoskelet Neuronal Interact. 2021 Sep 1;21(3):351-357.
OBJECTIVES
To explore complex correlations between obesity (OB) and osteoporosis (OP) after adjustment of static mechanical loading from weight and fat free mass (FFM).
METHODS
A total of 3749 Chinese aged ≥65 years were selected from our ongoing cohort study. OB indices and bone mineral density (BMD) were measured for each subject. Linear regression analyses were performed to explore the correlations between OB indices and OP under three adjustment models (unadjusted, adjusted with weight and adjusted with FFM).
RESULTS
Under no adjustment, three general obesity indices (body mass index: BMI, fat mass: FM, and percentage FM: PFM) were positively associated with BMD at three skeletal sites (P<0.001) in the regression analyses. However, after the adjustment with weight, these associations were mostly significant but reverse i.e., negatively in direction. After adjustment with FFM, the three indices were still positively and significantly (P<0.001) associated with BMD but regression coefficients were smaller compared to the unadjusted associations. Similar associations were observed for central adiposity and lower limb adiposity indices.
CONCLUSIONS
The combined relation of OB to OP due to the physiological factors secreted from adipose tissues and the static mechanical loading from FM is positive in direction.
目的
在调整体重和去脂体重（FFM）带来的静态机械负荷后，探索肥胖症（OB）与骨质疏松症（OP）之间的复杂关联。
方法
从我们正在进行的队列研究中，共选择了 3749 名年龄≥65 岁的中国老年人。为每位受试者测量肥胖指标和骨矿物质密度（BMD）。进行线性回归分析，以在三种调整模型（未调整、调整体重和调整 FFM）下探讨 OB 指标与 OP 之间的相关性。
结果
在未调整的情况下，三个一般肥胖指标（体重指数：BMI、脂肪量：FM 和脂肪百分比：PFM）在回归分析中与三个骨骼部位的 BMD 呈正相关（P<0.001）。然而，在调整体重后，这些关联大多仍然显著，但方向相反，即呈负相关。在调整 FFM 后，这三个指数仍然与 BMD 呈显著正相关（P<0.001），但与未调整的关联相比，回归系数较小。中央肥胖和下肢肥胖指标也观察到类似的关联。
结论
由于脂肪组织分泌的生理因素和 FM 带来的静态机械负荷，OB 与 OP 的综合关联呈正相关。
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