Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-4965, USA.
FASEB J. 2011 Feb;25(2):439-43. doi: 10.1096/fj.11-0202ufm.
The FASEB Journal is a pillar among biomedical publications, contributing greatly by disseminating the results of vision research during its lifetime. Progress over this period has been remarkable. George Wald provided the first chemical understanding of the fundamental processes governing vision: the photoisomerization of 11-cis-retinal to all-trans-retinal and the enzymatic regeneration of this chromophore. Contributions of this extraordinary scientist set the stage for discoveries ranging from gross recording of various electrical responses to light to elucidation of signal transduction at a structural level, and from characterization of retinal diseases to successful treatments.
《FASEB 杂志》是生物医学出版物的重要支柱之一，在其整个生命周期中为传播视觉研究成果做出了巨大贡献。在此期间取得了显著进展。乔治·沃尔德（George Wald）首次从化学角度理解了控制视觉的基本过程：11-顺式视黄醛向全反式视黄醛的光异构化，以及该生色团的酶再生。这位杰出科学家的贡献为从各种电响应到光的粗略记录，到结构水平的信号转导阐明，从视网膜疾病的特征到成功的治疗等一系列发现奠定了基础。
