乳链菌肽介导的基于膜成分物理化学特征的选择性毒性。
Lacticin Q-mediated selective toxicity depending on physicochemical features of membrane components.
机构信息
Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2446-50. doi: 10.1128/AAC.00808-10. Epub 2011 Jan 31.
Abstract
Lacticin Q, a lactococcal pore-forming bacteriocin, shows activity toward Gram-positive bacteria but not Gram-negative bacteria. Lacticin Q did not induce permeability of the outer membrane of Gram-negative bacteria. Experiments using model membranes containing outer membrane components suggested that lacticin Q binds to the outer membrane of Gram-negative bacteria but is unable to penetrate it. The lack of activity of lacticin Q was attributed to physicochemical features of the outer membrane components.
摘要
乳链菌肽 Q 是一种乳球菌素，对革兰氏阳性菌具有活性，而对革兰氏阴性菌没有活性。乳链菌肽 Q 不会诱导革兰氏阴性菌的外膜通透性增加。使用含有外膜成分的模型膜进行的实验表明，乳链菌肽 Q 与革兰氏阴性菌的外膜结合，但无法穿透它。乳链菌肽 Q 缺乏活性归因于外膜成分的物理化学特性。
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