Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Antimicrob Agents Chemother. 2011 May;55(5):2463-5. doi: 10.1128/AAC.01390-10. Epub 2011 Jan 31.
ACHN-490 was tested alone and in combination with cefepime, doripenem, imipenem, or piperacillin-tazobactam in a synergy time-kill analysis against 25 Pseudomonas aeruginosa strains with different resistance phenotypes. Each combination was synergistic against most isolates at 24 h, and antagonism was not observed. Combinations of ACHN-490 with cefepime, doripenem, imipenem, or piperacillin-tazobactam yielded synergies in ≥70% and ≥80% of strains at 6 and 12 h, respectively, and in ≥68% at 24 h.
ACHN-490 与头孢吡肟、多利培南、亚胺培南或哌拉西林他唑巴坦联合用于协同时间杀伤分析，以测试其对 25 株具有不同耐药表型的铜绿假单胞菌菌株的单独作用和联合作用。大多数分离株在 24 小时时，每种组合对大多数分离株均具有协同作用，且未观察到拮抗作用。ACHN-490 与头孢吡肟、多利培南、亚胺培南或哌拉西林他唑巴坦联合使用，在 6 小时和 12 小时时，分别在≥70%和≥80%的菌株中产生协同作用，在 24 小时时在≥68%的菌株中产生协同作用。
