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本文引用的文献

1
Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America.成人和儿童复杂性腹腔内感染的诊断和治疗：外科感染学会和美国传染病学会的指南。
Clin Infect Dis. 2010 Jan 15;50(2):133-64. doi: 10.1086/649554.
2
ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.ACHN-490，一种对多重耐药肺炎克雷伯菌分离株具有强大体外活性的新糖苷。
Antimicrob Agents Chemother. 2009 Oct;53(10):4504-7. doi: 10.1128/AAC.00556-09.
3
Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis.一名患有心内膜炎患者体内一株对达托霉素不敏感的万古霉素中介金黄色葡萄球菌菌株的特征分析。
Antimicrob Agents Chemother. 2007 Sep;51(9):3445-8. doi: 10.1128/AAC.00559-07. Epub 2007 Jul 9.
4
Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology.采用时间杀菌法评估达托霉素单独使用以及与利福平、庆大霉素联合使用对金黄色葡萄球菌的活性。
Antimicrob Agents Chemother. 2007 Apr;51(4):1504-7. doi: 10.1128/AAC.01455-06. Epub 2007 Jan 12.
5
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?泛发性杀白细胞素是社区获得性耐甲氧西林金黄色葡萄球菌疾病的主要毒力决定因素吗？
J Infect Dis. 2006 Dec 15;194(12):1761-70. doi: 10.1086/509506. Epub 2006 Nov 2.
6
Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.万古霉素中度敏感金黄色葡萄球菌中达托霉素敏感性降低与万古霉素耐药性之间的相关性
Antimicrob Agents Chemother. 2006 Mar;50(3):1079-82. doi: 10.1128/AAC.50.3.1079-1082.2006.
7
Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus.源自万古霉素中介金黄色葡萄球菌的新型抗生素耐药机制。
Antimicrob Agents Chemother. 2006 Feb;50(2):428-38. doi: 10.1128/AAC.50.2.428-438.2006.
8
Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States.一株在美国广泛传播的社区相关性耐甲氧西林金黄色葡萄球菌的特性分析。
J Clin Microbiol. 2006 Jan;44(1):108-18. doi: 10.1128/JCM.44.1.108-118.2006.
9
Control and outcome of a large outbreak of colonization and infection with glycopeptide-intermediate Staphylococcus aureus in an intensive care unit.重症监护病房中耐糖肽金黄色葡萄球菌定植与感染大规模暴发的控制及结果
Clin Infect Dis. 2006 Jan 15;42(2):170-8. doi: 10.1086/498898. Epub 2005 Dec 13.
10
A 1 year surveillance study of glycopeptide-intermediate Staphylococcus aureus strains in a French hospital.法国一家医院对糖肽类中介金黄色葡萄球菌菌株进行的为期1年的监测研究。
J Antimicrob Chemother. 2006 Jan;57(1):146-9. doi: 10.1093/jac/dki413. Epub 2005 Nov 14.

采用时间杀菌法检测 ACHN-490 单药及与其他药物联合的抗葡萄球菌活性。

Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.

机构信息

Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.

出版信息

Antimicrob Agents Chemother. 2010 May;54(5):2258-61. doi: 10.1128/AAC.01350-09. Epub 2010 Feb 9.

DOI:10.1128/AAC.01350-09
PMID:20145088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2863652/
Abstract

Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4 strains. ACHN-490 and ceftobiprole showed synergy in 17/47 strains tested at 24 h, while 6/47 strains showed synergy for subinhibitory combinations of ACHN-490 and linezolid.

摘要

协同时间杀菌研究显示，亚抑菌浓度ACHN-490 和达托霉素联合应用对 47 株不同耐药表型耐甲氧西林金黄色葡萄球菌中的 43 株在 24 小时时具有协同作用，而对其余 4 株则表现为无关。在 24 小时测试的 47 株菌株中，ACHN-490 和头孢托罗匹酯显示出协同作用，而亚抑菌浓度ACHN-490 和利奈唑胺联合应用对 6 株菌株显示出协同作用。