采用时间杀菌法检测 ACHN-490 单药及与其他药物联合的抗葡萄球菌活性。
Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.
机构信息
Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.
出版信息
Antimicrob Agents Chemother. 2010 May;54(5):2258-61. doi: 10.1128/AAC.01350-09. Epub 2010 Feb 9.
Abstract
Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4 strains. ACHN-490 and ceftobiprole showed synergy in 17/47 strains tested at 24 h, while 6/47 strains showed synergy for subinhibitory combinations of ACHN-490 and linezolid.
摘要
协同时间杀菌研究显示，亚抑菌浓度ACHN-490 和达托霉素联合应用对 47 株不同耐药表型耐甲氧西林金黄色葡萄球菌中的 43 株在 24 小时时具有协同作用，而对其余 4 株则表现为无关。在 24 小时测试的 47 株菌株中，ACHN-490 和头孢托罗匹酯显示出协同作用，而亚抑菌浓度ACHN-490 和利奈唑胺联合应用对 6 株菌株显示出协同作用。
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