National Creative Research Initiative Center for Oxide Nanocrystalline Materials, World Class University Program of Chemical Convergence for Energy and Environment, Seoul National University, Seoul 151-744, Korea.
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2662-7. doi: 10.1073/pnas.1016409108. Epub 2011 Jan 31.
For ultrasensitive magnetic resonance imaging (MRI), magnetic nanoparticles with extremely high r2 relaxivity are strongly desired. Magnetosome-like nanoparticles were prepared by coating polyethylene glycol-phospholipid (PEG-phospholipid) onto ferrimagnetic iron oxide nanocubes (FIONs). FIONs exhibited a very high relaxivity (r2) of 324 mM(-1) s(-1), allowing efficient labeling of various kinds of cells. The magnetic resonance (MR) imaging of single cells labeled with FIONs is demonstrated not only in vitro but also in vivo. Pancreatic islet grafts and their rejection could be imaged using FIONs on a 1.5 T clinical MRI scanner. The strong contrast effect of FIONs enabled MR imaging of transplanted islets in small rodents as well as in large animals. Therefore, we expect that MR imaging of pancreatic islet grafts using FIONs has the potentials for clinical applications. Furthermore, FIONs will enable highly sensitive noninvasive assessment after cell transplantation.
用于超高灵敏磁共振成像（MRI），强烈需要具有极高 r2 弛豫率的磁性纳米粒子。通过将聚乙二醇-磷脂（PEG-磷脂）涂覆到亚铁磁性氧化铁纳米立方体（FIONs）上，制备出类磁铁矿纳米粒子。FIONs 表现出非常高的弛豫率（r2）为 324 mM(-1) s(-1)，允许对各种细胞进行有效标记。用 FIONs 进行的体外和体内实验均证明了其对单离细胞的磁共振（MR）成像。使用 FIONs 在 1.5 T 临床 MRI 扫描仪上可以对胰岛移植物及其排斥进行成像。FIONs 的强对比效应使在小型啮齿动物和大型动物中对移植胰岛的磁共振成像成为可能。因此，我们期望使用 FIONs 对胰岛移植物进行的 MR 成像具有临床应用的潜力。此外，FIONs 将能够在细胞移植后进行高度灵敏的非侵入性评估。
Proc Natl Acad Sci U S A. 2011-1-31
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