Department of Advanced Materials and NanotechnologyPeking University, Beijing, People's Republic of China.
Adv Mater. 2010 Jul 6;22(25):2729-42. doi: 10.1002/adma.201000260.
Synthesis of multifunctional magnetic nanoparticles (MFMNPs) is one of the most active research areas in advanced materials. MFMNPs that have magnetic properties and other functionalities have been demonstrated to show great promise as multimodality imaging probes. Their multifunctional surfaces also allow rational conjugations of biological and drug molecules,making it possible to achieve target-specific diagnostics and therapeutics.This review fi rst outlines the synthesis of MNPs of metal oxides and alloy sand then focuses on recent developments in the fabrication of MFMNPs of core/shell, dumbbell, and composite hybrid type. It also summarizes the general strategies applied for NP surface functionalization. The review further highlights some exciting examples of these MFMNPs for multimodality imaging and for target-specific drug/gene delivery applications.
多功能磁性纳米粒子（MFMNPs）的合成是先进材料中最活跃的研究领域之一。具有磁性和其他功能的 MFMNPs 已被证明作为多模态成像探针具有很大的应用潜力。它们的多功能表面还允许生物和药物分子的合理共轭，从而实现靶向诊断和治疗。本综述首先概述了金属氧化物和合金的 MNPs 的合成，然后重点介绍了核/壳、哑铃和复合混合型 MFMNPs 的最新制备进展。它还总结了用于 NP 表面功能化的一般策略。该综述进一步强调了这些 MFMNPs 在多模态成像和靶向药物/基因传递应用方面的一些令人兴奋的例子。
