Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America.
PLoS One. 2011 Jan 21;6(1):e16359. doi: 10.1371/journal.pone.0016359.
Recent advancements in magnetic resonance imaging (MRI) have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. To this end, (1)H nuclear magnetic resonance (NMR) and high-resolution X-ray signals from human cortical bone samples were correlated with mechanical properties of bone. Results showed that (1)H NMR signals were better predictors of yield stress, peak stress, and pre-yield toughness than were the X-ray derived signals. These (1)H NMR signals can, in principle, be extracted from clinical MRI, thus offering the potential for improved clinical assessment of fracture risk.
磁共振成像（MRI）的最新进展使得对人体皮质骨的临床成像成为可能，为评估骨健康提供了一种潜在的强大新方法，其分子级灵敏度是传统基于 X 射线的诊断方法所无法达到的。为此，（1）H 核磁共振（NMR）和来自人体皮质骨样本的高分辨率 X 射线信号与骨的机械性能相关联。结果表明，（1）H NMR 信号比 X 射线衍生信号更能预测屈服应力、峰值应力和预屈服韧性。这些（1）H NMR 信号原则上可以从临床 MRI 中提取，从而有可能改善对骨折风险的临床评估。
