中国-缅甸边境地区中缅两国静脉注射吸毒者中 HIV、HBV、HCV 及合并感染的流行率比较。

Comparison of HIV-, HBV-, HCV- and co-infection prevalence between Chinese and Burmese intravenous drug users of the China-Myanmar border region.

机构信息

Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

出版信息

PLoS One. 2011 Jan 21;6(1):e16349. doi: 10.1371/journal.pone.0016349.

DOI:10.1371/journal.pone.0016349

PMID:21283696

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3025010/

Abstract

BACKGROUND

Co-infection with HIV and HCV and/or HBV is highly prevalent in intravenous drug users (IDUs). Because of the proximity to the "Golden Triangle", HIV prevalence among the IDUs is very high in the China-Myanmar border region. However, there are few studies about co-infection with HIV and HCV and/or HBV, especially in the region that belongs to Myanmar.

METHODS

721 IDUs, including 403 Chinese and 318 Burmese, were investigated for their HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) serological status. Statistical analysis was performed to evaluate the differences of the epidemic situation between the Chinese IDUs and the Burmese IDUs.

RESULTS

Among the Chinese IDUs and the Burmese IDUs, HCV infection was the most prevalent (69.0% vs 48.1%, P<0.001), followed by HBV (51.6% vs 43.1%, P<0.05) and HIV (33.7% vs 27.0%, P>0.05). Besides, there were more HIV-HBV co-infected IDUs (20.1% vs 11.3%, P<0.005), and HIV-HCV co-infected IDUs (31.8% vs 23.9%, P<0.05) in China than in Myanmar, as well as HIV-HBV-HCV triple infection (19.1% vs 10.4%, P<0.005).

CONCLUSION

Co-infection with HIV and HCV and/or HBV is highly prevalent among the IDUs in the China-Myanmar border region. The HIV epidemic appears to be in a downward trend, compared with previous reports. However, all infections were more prevalent among the Chinese IDUs than among the Burmese.

摘要

背景

在中国-缅甸边境地区，静脉吸毒者（IDUs）中 HIV 与 HCV 和/或 HBV 的合并感染非常普遍。由于临近“金三角”，该地区 IDUs 的 HIV 流行率非常高。然而，关于 HIV 与 HCV 和/或 HBV 的合并感染的研究很少，特别是在属于缅甸的地区。

方法

调查了 721 名 IDU，包括 403 名中国 IDU 和 318 名缅甸 IDU，以检测他们的 HIV、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）血清学状况。进行统计分析以评估中国 IDU 和缅甸 IDU 之间流行情况的差异。

结果

在中国 IDU 和缅甸 IDU 中，HCV 感染最为普遍（69.0% vs 48.1%，P<0.001），其次是 HBV（51.6% vs 43.1%，P<0.05）和 HIV（33.7% vs 27.0%，P>0.05）。此外，中国 IDU 中 HIV-HBV 合并感染 IDU （20.1% vs 11.3%，P<0.005）和 HIV-HCV 合并感染 IDU（31.8% vs 23.9%，P<0.05）的比例高于缅甸 IDU，HIV-HBV-HCV 三重感染（19.1% vs 10.4%，P<0.005）的比例也高于缅甸 IDU。