Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
Org Biomol Chem. 2011 Mar 21;9(6):1864-70. doi: 10.1039/c0ob00847h. Epub 2011 Jan 31.
Herein, we report the synthesis of novel phenylalanine and tyrosine derivatives containing a N-methyliminodiacetic acid boronate group. These compounds can be prepared enantiomerically pure, they are stable to column chromatography and they can be stored in air for two months without degradation occurring. This new class of boronate containing aromatic amino acids has potential applications in both peptide chemistry and natural product synthesis.
在此，我们报告了新型苯丙氨酸和酪氨酸衍生物的合成，这些衍生物含有 N-甲基亚氨基二乙酸硼酸酯基团。这些化合物可以制备成对映体纯的形式，它们在柱层析过程中稳定，在空气中储存两个月也不会发生降解。这种新型含硼酸酯的芳香族氨基酸在肽化学和天然产物合成中都有潜在的应用。
