Division of General Internal Medicine, University of Mississippi Medical Center, Jackson, USA.
Horm Metab Res. 2011 Mar;43(3):153-64. doi: 10.1055/s-0030-1270521. Epub 2011 Jan 31.
Testosterone deficiency (TD) has become a frequently diagnosed condition in our current society with an obesity epidemic. Men diagnosed with TD often have co-morbidities including metabolic syndrome. Challenging aspects in diagnosing and treating patients with TD include intra-individual variation of symptoms combined with lack of its correlation with serum levels of testosterone. Apart from sexual aspects including libido and erectile function, replacement therapy with testosterone might have beneficial metabolic effects, whereas untreated TD might increase cardiometabolic risk and disease. In this article, we review the cardiovascular and metabolic risks associated with TD, as well as risks and benefits of testosterone replacement therapy. We also provide insights into potential mechanisms of the association between cardiometabolic risks with TD (treated and untreated) and propose an individual treatment algorithm.
睾酮缺乏症（TD）在肥胖症流行的当今社会已成为一种常见的诊断病症。被诊断患有 TD 的男性常伴有合并症，包括代谢综合征。诊断和治疗 TD 患者的挑战性方面包括症状的个体内差异，以及其与血清睾酮水平缺乏相关性。除了性欲和勃起功能等性方面，睾酮替代疗法可能具有有益的代谢作用，而未经治疗的 TD 可能会增加心血管代谢风险和疾病。本文综述了与 TD 相关的心血管和代谢风险，以及睾酮替代疗法的风险和益处。我们还深入探讨了代谢风险与 TD（治疗和未治疗）之间的关联的潜在机制，并提出了个体化治疗算法。
