Department of Biochemistry, Division of Urology, Boston University School of Medicine, Mass., USA.
Am J Med. 2011 Jul;124(7):578-87. doi: 10.1016/j.amjmed.2010.12.027.
Testosterone deficiency (TD) afflicts approximately 30% of men aged 40-79 years, with an increase in prevalence strongly associated with aging and common medical conditions including obesity, diabetes, and hypertension. A strong relationship is noted between TD and metabolic syndrome, although the relationship is not certain to be causal. Repletion of testosterone (T) in T-deficient men with these comorbidities may indeed reverse or delay their progression. While T repletion has been largely thought of in a sexual realm, we discuss its potential role in general men's health concerns: metabolic, body composition, and all-cause mortality through the use of a single clinical vignette. This review examines a host of studies, with practical recommendations for diagnosis of TD and T repletion in middle-aged and older men, including an analysis of treatment modalities and areas of concerns and uncertainty.
睾酮缺乏症（TD）影响了大约 30%的 40-79 岁男性，其患病率的增加与衰老以及肥胖、糖尿病和高血压等常见疾病密切相关。TD 与代谢综合征之间存在很强的关联，尽管这种关联不一定是因果关系。在患有这些合并症的 TD 男性中补充睾酮（T）确实可以逆转或延缓其进展。虽然 T 补充剂在很大程度上被认为与性功能有关，但我们通过一个临床案例讨论了它在一般男性健康问题方面的潜在作用：代谢、身体成分和全因死亡率。本综述考察了大量的研究，对中年和老年男性 TD 及 T 补充的诊断提出了实用建议，包括对治疗方式以及关注和不确定的领域进行了分析。
