大鼠皮质下白质少突胶质细胞的年龄相关性变化。
Age-related changes of the oligodendrocytes in rat subcortical white matter.
机构信息
Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
出版信息
Anat Rec (Hoboken). 2011 Mar;294(3):487-93. doi: 10.1002/ar.21332. Epub 2011 Jan 31.
The age-related changes, of the oligodendrocytes in rat subcortical white matter, were investigated in this study. The oligodendrocytes in subcortical white matter were labeled with anti-2',3'-cyclic nucleotide 3'-phosphodiesterase antibody (anti-CNPase antibody, a specific marker of oligodendrocytes). The total number of CNPase(+) cells was estimated with an unbiased stereological technique, the optical fractionator. In this study, we found that the total number of CNPase(+) cells in the young male rats and aged male rats was 14.4 ± 1.2 × 10(6) and 9.0 ± 1.0 × 10(6) , respectively. The total number of the CNPase(+) cells in the subcortical white matter of aged rats was significantly decreased by 37.5% when compared to young male rats. This study demonstrated that there was an aged-related decrease of the oligodendrocytes in subcortical white matter.
本研究旨在探讨大鼠皮质下白质少突胶质细胞的年龄相关性变化。使用抗 2'，3'-环核苷酸 3'-磷酸二酯酶抗体（抗 CNPase 抗体，少突胶质细胞的特异性标志物）对皮质下白质中的少突胶质细胞进行标记。使用无偏立体学技术——光学分束器估计 CNPase(+)细胞的总数。在这项研究中，我们发现年轻雄性大鼠和老年雄性大鼠的 CNPase(+)细胞总数分别为 14.4±1.2×10(6)和 9.0±1.0×10(6)。与年轻雄性大鼠相比，老年大鼠皮质下白质的 CNPase(+)细胞总数显著减少了 37.5%。本研究表明，皮质下白质中的少突胶质细胞存在与年龄相关的减少。
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