Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
J Periodontol. 2011 Oct;82(10):1396-403. doi: 10.1902/jop.2011.100731. Epub 2011 Feb 2.
Platelet-rich fibrin (PRF), an intimate assembly of cytokines, glycan chains, and structural glycoproteins enmeshed within a slowly polymerized fibrin network, has the potential to accelerate soft and hard tissue healing. This double-masked randomized study is designed to evaluate the effectiveness of autologous PRF in the treatment of mandibular degree II furcation defects compared with open flap debridement (OFD).
Using a split-mouth design, 18 patients with 36 mandibular degree II furcation defects were randomly allotted and treated either with autologous PRF and OFD or OFD. Plaque index, sulcus bleeding index, probing depth, relative vertical and horizontal clinical attachment level, gingival marginal level, and radiographic bone defect were recorded at baseline and 9 months postoperatively. Comparison between indices between the test and control groups was performed using the paired t test except for plaque index and sulcus bleeding index data, which used the χ(2) test.
All clinical and radiographic parameters showed statistically significant improvement at the sites treated with PRF and OFD compared to those with OFD alone.
Within the limitation of this study, significant improvement with autologous PRF implies its role as a regenerative material in the treatment of furcation defects.
富含血小板纤维蛋白（PRF）是细胞因子、糖链和结构糖蛋白的紧密组合，交织在缓慢聚合的纤维蛋白网络中，具有加速软组织和硬组织愈合的潜力。这项双盲随机研究旨在评估与开放式翻瓣清创术（OFD）相比，自体 PRF 治疗下颌 II 度分叉缺损的疗效。
采用分口设计，将 18 名患者的 36 个下颌 II 度分叉缺损随机分为自体 PRF 和 OFD 组或 OFD 组。在基线和术后 9 个月时记录菌斑指数、探诊出血指数、探诊深度、相对垂直和水平临床附着水平、牙龈边缘水平和放射影像学骨缺损。除菌斑指数和探诊出血指数数据外，使用 χ(2)检验比较试验组和对照组之间的指数，其余使用配对 t 检验。
与单独 OFD 相比，PRF 和 OFD 治疗部位的所有临床和放射影像学参数均显示出统计学显著改善。
在本研究的限制范围内，自体 PRF 的显著改善表明其在治疗分叉缺损中的再生材料作用。
