Baraldi E, Montini G, Zanconato S, Zacchello G, Zacchello F
Department of Paediatrics, University of Padua, Italy.
Pediatr Nephrol. 1990 Nov;4(6):623-6. doi: 10.1007/BF00858638.
The aim of this study was to evaluate the effect of correction of chronic anaemia on the physical performance and the cardiovascular response to effort in children with end-stage renal disease (ESRD) maintained by haemodialysis. Seven patients (mean age 13.9 years) underwent triangular-type treadmill exercise testing before [haemoglobin (Hb) 6.3 +/- 0.9 g/dl] and after (Hb 11.2 +/- 1.2 g/dl) anaemia correction with recombinant human erythropoietin (rHuEPO). After treatment, the work-load reached, the peak oxygen uptake and average ventilatory anaerobic threshold (VAT) values were significantly increased (P less than 0.01, P less than 0.001, P less than 0.05 respectively). VAT values, expressed as a percentage of normal values, increased from 55.7 +/- 16.6% to 82.4 +/- 21%. This improvement correlated well with the increase in Hb (r = 0.79). Oxygen pulse also increased significantly, when tested after anaemia correction. In conclusion, these data demonstrate that when the anaemia of children with ESRD is corrected with rHuEPO, there is a clear improvement in aerobic work capacity and effort tolerance.
本研究的目的是评估纠正慢性贫血对接受血液透析维持治疗的终末期肾病（ESRD）患儿身体机能及运动时心血管反应的影响。7例患者（平均年龄13.9岁）在使用重组人促红细胞生成素（rHuEPO）纠正贫血前[血红蛋白（Hb）6.3±0.9 g/dl]和纠正后（Hb 11.2±1.2 g/dl）接受了三角型跑步机运动测试。治疗后，达到的工作量、峰值摄氧量和平均通气无氧阈（VAT）值均显著增加（分别为P<0.01、P<0.001、P<0.05）。以正常值百分比表示的VAT值从55.7±16.6%增至82.4±21%。这一改善与Hb的增加密切相关（r=0.79）。贫血纠正后进行测试时，氧脉搏也显著增加。总之，这些数据表明，用rHuEPO纠正ESRD患儿的贫血后，有氧工作能力和运动耐力有明显改善。
