Reybrouck T, Weymans M, Stijns H, van der Hauwaert L G
Pediatr Cardiol. 1986;7(1):19-24. doi: 10.1007/BF02315477.
The ventilatory response to graded treadmill exercise was studied in 50 children with congenital heart disease (CHD), a left-to-right intracardiac shunt, and compared to that of age and sex-matched healthy children. In all these children, a breakpoint in the minute ventilation (VE) in relation to increasing oxygen uptake (VO2) was detected. Because of the reported coincidence of the nonlinear increase in VE and lactate with increasing VO2, this threshold has been named "ventilatory anaerobic threshold" (VAT), expressed in ml O2 X min-1 X kg-1. VAT correlated well with VO2 (ml X min-1 X kg-1), reached at a heart rate of 170/min (VO2,170). Compared to normal children, however, a significantly (p less than 0.05) larger percentage (56%) of the patients showed a subnormal value (below the 95% confidence limit) for VAT than for VO2,170 (28%). Furthermore, when expressed as a percentage of the mean normal value, the mean VAT (89 +/- 14.4% SD) was significantly (p less than 0.05) lower than the mean VO2,170 (103 +/- 17.2%). VAT (ml O2 X min-1) correlated significantly with body weight and height, even after adjusting for age, and with the percentiles of body weight and height. VAT constitutes a useful noninvasive criterion for evaluating exercise performance in children with CHD, at least those forms with a left-to-right intracardiac shunt, and it is significantly more sensitive than the VO2,170 in detecting decreased cardiorespiratory endurance capacity.
对50名患有先天性心脏病（CHD）且存在心内左向右分流的儿童进行了分级跑步机运动的通气反应研究，并与年龄和性别匹配的健康儿童进行了比较。在所有这些儿童中，检测到分钟通气量（VE）相对于摄氧量（VO2）增加时的一个断点。由于据报道VE和乳酸随VO2增加的非线性增加具有一致性，这个阈值被命名为“通气无氧阈”（VAT），以ml O2×min-1×kg-1表示。VAT与VO2（ml×min-1×kg-1）相关性良好，在心率为170次/分钟（VO2,170）时达到。然而，与正常儿童相比，有显著更高比例（56%）的患者VAT值低于正常值（低于95%置信限），而VO2,170低于正常值的比例为28%（p<0.05）。此外，当以正常平均值的百分比表示时，平均VAT（89±14.4%标准差）显著低于平均VO2,170（103±17.2%）（p<0.05）。即使在调整年龄后，VAT（ml O2×min-1）与体重和身高仍显著相关，并且与体重和身高百分位数相关。VAT是评估患有CHD儿童运动表现的一个有用的非侵入性标准，至少对于那些存在心内左向右分流的类型是如此，并且在检测心肺耐力能力下降方面，它比VO2,170明显更敏感。
