头孢呋辛酯与普鲁卡因青霉素治疗单纯性淋病的对比研究。

Comparative study of cefuroxime axetil and procaine penicillin in the treatment of uncomplicated gonorrhoea.

作者信息

Kinghorn G R, Spencer R C, Smith T K, Woolley P D, Patel R, Robinson A J

机构信息

Department of Genitourinary Medicine, Royal Hallamshire Hospital, Sheffield, UK.

出版信息

Int J STD AIDS. 1990 Jul;1(4):285-7. doi: 10.1177/095646249000100412.

DOI:10.1177/095646249000100412

PMID:2128472

Abstract

A total of 311 patients presenting with uncomplicated gonorrhoea were entered into a comparative randomized open-label study and given single-dose treatment with either oral cefuroxime axetil (CAE) or intramuscular procaine penicillin (PP). Neisseria gonorrhoeae was eliminated from 129 (98%) of 131 evaluable patients treated with CAE and 127 (98%) of 129 evaluable patients treated with PP. None of the 4 treatment failures (3 male and 1 female) were caused by beta-lactamase-producing isolates. Both treatments were well tolerated with minor adverse events reported in 3 (2%) of CAE treated patients. We conclude that CAE is an effective, well tolerated treatment for uncomplicated gonorrhoea which has the convenience and acceptability of single-dose oral therapy.

摘要

共有311例单纯性淋病患者进入一项比较性随机开放标签研究，接受单剂量口服头孢呋辛酯（CAE）或肌肉注射普鲁卡因青霉素（PP）治疗。接受CAE治疗的131例可评估患者中有129例（98%）淋病奈瑟菌被清除，接受PP治疗的129例可评估患者中有127例（98%）淋病奈瑟菌被清除。4例治疗失败患者（3例男性和1例女性）均非由产β-内酰胺酶菌株引起。两种治疗耐受性均良好，CAE治疗患者中有3例（2%）报告有轻微不良事件。我们得出结论，CAE是治疗单纯性淋病的一种有效且耐受性良好的疗法，具有单剂量口服治疗的便利性和可接受性。