Department of Molecular Biology and National Centre of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland.
Cell Metab. 2011 Feb 2;13(2):125-37. doi: 10.1016/j.cmet.2011.01.006.
In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK, NPAS2, and HSF1), nutrient-sensing transcriptional regulatory proteins (e.g., CREB-CBP-CRCT2, FOXO-p300, nuclear receptors, PGC-1, and SP1 family members) and protein kinases (e.g., AMPK), are plausible candidates for conveying a cell's metabolic state to the core clock circuitry. The intertwining between these acute regulators and circadian clock components is so tight that the discrimination between metabolic and circadian oscillations may be somewhat arbitrary.
在哺乳动物中，大多数代谢过程受生物钟和摄食节律的影响。将代谢与昼夜节律振荡器联系起来的机制才刚刚开始出现。NAD 依赖性酶（如 Sirtuins 和多聚[ADP-核糖]聚合酶）、氧化还原和/或温度依赖性转录因子（如 CLOCK、NPAS2 和 HSF1）、营养感应转录调节蛋白（如 CREB-CBP-CRCT2、FOXO-p300、核受体、PGC-1 和 SP1 家族成员）和蛋白激酶（如 AMPK），是将细胞的代谢状态传递给核心时钟电路的合理候选者。这些急性调节剂和昼夜节律钟成分之间的交织非常紧密，以至于代谢和昼夜节律振荡之间的区分可能有些任意。
