探讨认知储备在早发性痴呆中的作用。
Exploring the role of cognitive reserve in early-onset dementia.
机构信息
Neurosciences Unit, Graylands Hospital and Health Services, Mt Claremont, WA, Australia.
出版信息
Am J Alzheimers Dis Other Demen. 2011 Mar;26(2):139-44. doi: 10.1177/1533317510397328. Epub 2011 Jan 31.
AIM
Cognitive reserve (CR) is important in protecting the brain from injury and has not been investigated in people with early-onset dementia (EOD).
METHODS
A retrospective case control study of 44 patients with dementia onset prior to 65 years of age: Alzheimer's disease (AD) = 23; frontotemporal dementia (FTD) = 21. Groups were matched for age, education, Mini-Mental State Examination (MMSE), premorbid IQ, sex and APOE ε4 genotype. Years of formal education were used as a marker of CR. Relationships between education and neuropsychological data was examined using linear regression analyses.
RESULTS
There were no demographic differences between the AD and FTD groups. Significant associations were found between education and attention, working memory and visuospatial abilities. There was an effect of CR for the EOD group and selective effects in FTD and AD.
CONCLUSION
Our findings suggest CR is operational in patients with FTD and AD.
目的
认知储备（CR）对于保护大脑免受损伤很重要，但尚未在早发性痴呆（EOD）人群中进行研究。
方法
对 44 名发病年龄在 65 岁以下的痴呆患者进行回顾性病例对照研究：阿尔茨海默病（AD）= 23 例；额颞叶痴呆（FTD）= 21 例。两组在年龄、教育程度、简易精神状态检查（MMSE）、发病前智商、性别和 APOE ε4 基因型方面相匹配。受正规教育年限被用作 CR 的标志物。使用线性回归分析检查了教育与神经心理学数据之间的关系。
结果
AD 和 FTD 组之间在人口统计学上没有差异。教育程度与注意力、工作记忆和视空间能力显著相关。EOD 组存在 CR 效应，FTD 和 AD 组存在选择性效应。
结论
我们的研究结果表明，在 FTD 和 AD 患者中，CR 是可行的。
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