验证 Addenbrooke's 认知测验 III 在额颞叶痴呆和阿尔茨海默病中的应用。
Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease.
机构信息
Neuroscience Research Australia, Sydney, N.S.W., Australia.
出版信息
Dement Geriatr Cogn Disord. 2013;36(3-4):242-50. doi: 10.1159/000351671. Epub 2013 Aug 15.
BACKGROUND/AIMS: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia.
METHODS
A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study.
RESULTS
ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity.
CONCLUSION
The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.
背景/目的：本研究旨在验证新开发的 Addenbrooke 认知测验（ACE-III）在早期痴呆症中针对标准化神经心理学测试及其前身（ACE-R）的有效性。
方法
共有 61 名痴呆症患者（额颞叶痴呆症，FTD，n = 33，阿尔茨海默病，AD，n = 28）和 25 名对照者纳入了该研究。
结果
ACE-III 认知域与用于评估注意力、语言、言语记忆和视空间功能的标准化神经心理学测试显著相关。ACE-III 与前身 ACE-R 的比较也非常有利，具有相似的敏感性和特异性。
结论
本研究的结果为 ACE-III 作为 FTD 和 AD 认知缺陷的筛查工具提供了客观的验证。
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