Department of Medicine and NYU Cancer Institute, New York, NY 10016, USA.
Ann Oncol. 2011 Jan;22 Suppl 1:i50-2. doi: 10.1093/annonc/mdq666.
Measures to prevent breast cancer are receiving particular attention by women at high risk from either clinico-pathologic findings or genetic susceptibility. Life-style and nutritional interventions have been difficult to quantify, but merit further study. Chemoprevention with tamoxifen and subsequently with the related raloxifene demonstrates some efficacy, but may be not be applicable to premenopausal women (with regard to raloxifene), or have low acceptance (with regard to tamoxifen). Based on the importance of the insulin-like growth factor-1 pathway in mammary gland development, and the availability of a potent inhibitor, pilot studies are ongoing to evaluate such an inhibitor in women with demonstrable high risk to develop breast cancer. Short-term interventions with the inhibitor have been completed, and subsequent interventions are planned.
预防乳腺癌的措施正受到高危人群（基于临床病理发现或遗传易感性）的特别关注。生活方式和营养干预措施难以量化，但值得进一步研究。他莫昔芬和随后的雷洛昔芬的化学预防显示出一定的疗效，但可能不适用于绝经前妇女（关于雷洛昔芬），或接受度低（关于他莫昔芬）。基于胰岛素样生长因子-1 通路在乳腺发育中的重要性，以及有效的抑制剂的可用性，正在进行初步研究，以评估这种抑制剂在具有明显乳腺癌高风险的女性中的作用。抑制剂的短期干预已经完成，随后的干预计划正在进行中。
