从链霉菌 N05WA963 中发现的三种新型安古霉素类化合物。

Three novel members of angucycline group from Streptomyces sp. N05WA963.

机构信息

New Drug Research and Development Center, North China Pharmaceutical Group Corporation, National Microbial Medicine Engineering and Research Center, Hebei, PR China.

出版信息

J Antibiot (Tokyo). 2011 Apr;64(4):339-43. doi: 10.1038/ja.2011.4. Epub 2011 Feb 2.

DOI:10.1038/ja.2011.4

PMID:21285963

Abstract

Three novel members of angucycline family named N05WA963A (1), B (2) and D (4), together with a new anthracycline named N05WA963C (3) were isolated from the culture broth of Streptomyces sp. N05WA963. The structures were elucidated on the basis of comprehensive spectral data analysis. All four compounds have shown antiproliferative effects on a panel of cancer cell lines such as SW620, K-562, MDA-MB-231, YES-4, T-98 and U251SP.

摘要

从链霉菌 N05WA963 的发酵液中分离得到三个新的安库霉素家族成员 N05WA963A（1）、B（2）和 D（4），以及一个新的蒽环类化合物 N05WA963C（3）。根据综合光谱数据分析确定了它们的结构。这四个化合物均对 SW620、K-562、MDA-MB-231、YES-4、T-98 和 U251SP 等一系列癌细胞系具有抗增殖作用。